I5159

Imiquimod

≥98% (HPLC), solid, caspase 3 activator

• Sinónimos: 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
• Fórmula empírica (notación de Hill): C₁₄H₁₆N₄
• Número de CAS: 99011-02-6
• Peso molecular: 240.30
• Número MDL: MFCD00866946
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24724516
• NACRES: NA.77

Propiedades

• Nombre del producto: Imiquimod, ≥98% (HPLC), solid
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• solubilidad: H₂O: <2 mg/mL; DMSO: 4 mg/mL (warming to 60 °C for 15 minutes)
• cadena SMILES: CC(C)Cn1cnc2c(N)nc3ccccc3c12
• InChI: 1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
• Clave InChI: DOUYETYNHWVLEO-UHFFFAOYSA-N
• Información sobre el gen: human ... TLR7(51284)

Descripción

Descripción general

Imiquimod is a toll-like receptor (TLR)-7/8 agonist.

Aplicación

Imiquimod has been used as TLR7 agonist for TLR7 agonist enhancement studies. It has also been used as an NLR family, pyrin domain containing 3 (NLRP3) stimulant to treat NLRP3-FL-Btn and FLAG-ASC-FL.

Acciones bioquímicas o fisiológicas

Imiquimod helps to induce the innate cutaneous immunity and the cellular arm of the adaptive immune response.

Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo in basal cell carcinoma. Its anti-tumor activity is related to the induction of apoptosis. Imiquimod has anti-angiogenic, anti-inflammatory, anti-viral activities. Imiquimod also acts as an immune response modulator inducing the secretion of various cytokines and chemokines.

Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo and acts as an immunomodulator with anti-viral and anti-inflammatory perties.

Características y beneficios

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301,H315,H319
• Consejos de prudencia: P264 - P270 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges