I4028

Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse

clone 70625.111, purified immunoglobulin, lyophilized powder

• Sinónimos: Anti-IL-18 Receptor
• MDL number: MFCD02096767
• UNSPSC Code: 51111800
• NACRES: NA.41

Propiedades

• biological source: mouse
• Quality Level: 200
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 70625.111, monoclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): flow cytometry: suitable (2.5μg/SUP>10^{6 cell)}; immunocytochemistry: 8-25 μg/mL; immunohistochemistry: 8-25 μg/mL
• isotype: IgG1
• UniProt accession no.: Q13478
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... IL18R1(8809)

Descripción

General description

The antibody will neutralize the biological activity of recombinant human IL-18 receptor.

Immunogen

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

Biochem/physiol Actions

IL-18 belongs to the IL-1 cytokine superfamily and is a regulator of innate and acquired immune responses. The immune responses of IL-18 are mediated by its interaction and subsequent signaling by IL-18 receptor complex. The IL-18R complex is made up of α chain that binds to extracellular IL-18 and a β chain that is involved in signal transduction. The IL-18/IL-18R signaling enhances T and NK cell maturation, cytotoxicity and secretion of cytokines.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Preparation Note

Purified using protein G.

Información de seguridad

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable