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H5916

Sigma-Aldrich

Human Growth Hormone

HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

Sinónimos:

HGH, somatotropin

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.77

Nombre del producto

Human Growth Hormone human, HGH, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

origen biológico

human

Nivel de calidad

100

recombinante

expressed in HEK 293 cells

Ensayo

≥95% (SDS-PAGE)

Formulario

lyophilized powder

potencia

≤0.5 ng/mL EC50

mol peso

monomer 22 kDa (non-glycosylated)

envase

pkg of 10 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

técnicas

cell culture | mammalian: suitable

impurezas

≤1 EU/mg

temp. de almacenamiento

−20°C

Descripción general

Human growth hormone (HGH), also called somatotropin, is a peptide hormone that consists of a long single chain of amino acids. It is naturally secreted by somatotropic cells in the anterior pituitary gland of the human body.

Aplicación

Human Growth Hormone human has been used as a supplement in culture media to study its effect on the immune response in fish cell lines. It has also been used as a supplement in biliary differentiation medium (BDM) for differentiation of human embryonic stem cells (hESCs)/ human induced pluripotent stem cells (hiPSCs)-derived hepatoblasts.

Acciones bioquímicas o fisiológicas

Human growth hormone (HGH) is required for normal human growth and development. HGH modifies a variety of physiological functions by stimulating the expression of insulin-like growth factor I and increases calcium retention and bone density. HGH increases muscle mass, promotes lipolysis, and reduces liver uptake of glucose. Abnormalities in the regulation of HGH lead to various growth disorders such as gigantism or acromegaly due to hypersecretion of HGH. Conversely, HGH deficiency leads to growth deficit in children and GH deficiency syndrome in adults.

Forma física

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Nota de preparación

HumanKine, Human Growth Hormone (HGH) is expressed as a non-glycosylated monomer in human HEK 293 cells and has an apparent molecular mass of 22 kDa.

Nota de análisis

The activity was determined by the dose-dependent stimulation of the proliferation of rat lymphoma line Nb2-11 cells (prolactin indicator cell line).

Información legal

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Aplicación

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCV9218
MKCV4172
MKCR2874
MKCQ6192
MKCP1889

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J P Pontigo et al.
General and comparative endocrinology, 300, 113631-113631 (2020-10-04)
To clarify the role of growth hormone (GH) in the immune system of fish, we examine the comparative effect of GH and Growth Hormone Release Factor (GRF) on leukocytes culture of the head kidney of Atlantic salmon and the SHK-1
Maximilian Bielohuby et al.
Disease models & mechanisms, 7(11), 1263-1273 (2014-09-23)
The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in clinical practice. However, intact
Maïté Verreault et al.
Clinical and translational medicine, 12(7), e939-e939 (2022-07-10)
New therapeutic approaches are needed to improve the prognosis of glioblastoma (GBM) patients. With the objective of identifying alternative oncogenic mechanisms to abnormally activated epidermal growth factor receptor (EGFR) signalling, one of the most common oncogenic mechanisms in GBM, we
Wen-Jen Chung et al.
Protein expression and purification, 110, 79-88 (2015-02-24)
Growth hormone (GH) performs important roles in regulating somatic growth, reproduction, osmoregulation, metabolism and immunity in teleosts, and thus, it has attracted substantial attention in the field of aquaculture application. Herein, giant grouper GH (ggGH) cDNA was cloned into the
Noushin Dianat et al.
Hepatology (Baltimore, Md.), 60(2), 700-714 (2014-04-10)
Cholangiocytes are biliary epithelial cells, which, like hepatocytes, originate from hepatoblasts during embryonic development. In this study we investigated the potential of human embryonic stem cells (hESCs) to differentiate into cholangiocytes and we report a new approach, which drives differentiation

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Discover answers to your frequently asked questions about animal component-free, xenobiotic-free, and chemically defined media and reagents for cell culture.

Chromatograms

application for HPLC

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