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F7807

Sigma-Aldrich

Prostaglandin F Synthase human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sinónimos:

17-beta-hydroxysteroid dehydrogenase type 5, AKR1C3, aldo-keto reductase family 1 member C3, indanol dehydrogenase

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About This Item

Número de CAS:
55976-95-9
Comisión internacional de enzimas:
1.1.1.188 (BRENDA, IUBMB)
UNSPSC Code:
12352204
NACRES:
NA.54

recombinant

expressed in E. coli

Quality Level

200

description

contains a C-terminal hexahistidine tag

assay

≥90% (SDS-PAGE)

form

liquid

specific activity

≥0.4 μmol/mg protein

mol wt

~37 kDa

NCBI accession no.

NP_003730

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... AKR1C3(8644)

Application

Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .

Biochem/physiol Actions

PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .

Unit Definition

One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37°C in 50 mM KPO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Michal H Wrobel et al.
Toxicology, 262(3), 224-229 (2009-06-25)
Polychlorinated biphenyls (PCBs) stimulate in vitro both the force of myometrial contractions and endometrial secretion of PGF2alpha in cattle. Therefore, the goal of this study was to investigate the participation of PGF2alpha in the effect of PCBs on uterine contractility.
Agnieszka Waclawik et al.
Reproduction (Cambridge, England), 140(4), 613-622 (2010-07-10)
Oxytocin (OXT) and tumor necrosis factor α (TNF) have been implicated in the control of luteolysis by stimulating endometrial secretion of luteolytic prostaglandin F(2α) (PGF(2α)). Nevertheless, OXT concentration in porcine uterine lumen increases markedly on days 11-12 of pregnancy, and
[Prostaglandin synthases with thioredoxin domain].
Kikuko Watanabe
Seikagaku. The Journal of Japanese Biochemical Society, 82(11), 1041-1046 (2011-01-14)
Trevor M Penning et al.
Annals of the New York Academy of Sciences, 1155, 33-42 (2009-03-03)
Prostate and breast cancer are hormone-dependent malignancies of the aging male and female and require the local production of androgens and estrogens to stimulate cell proliferation. Aldo-keto reductases (AKR) play key roles in this process. In the prostate, AKR1C3 (type
Mariusz Pawel Kowalewski et al.
Animal reproduction science, 116(1-2), 129-138 (2009-01-24)
In nonpregnant and pregnant dogs the corpora lutea (CL) are the only source of progesterone (P4) which shows an almost identical secretion pattern until the rapid decrease of P4 prior to parturition. For the nonpregnant dog clear evidence has been
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