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Merck
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F0504

Sigma-Aldrich

Folate binding protein from bovine milk

lyophilized powder

Sinónimos:

Folate Protein

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About This Item

Número MDL:
MFCD00131098
Código UNSPSC:
12352202
NACRES:
NA.61

origen biológico

bovine milk

Nivel de calidad

200

Formulario

lyophilized powder

uso

 mg sufficient for ~4,000 assays

composición

Protein, 20-40% modified Warburg-Christian

técnicas

ligand binding assay: suitable
surface plasmon resonance (SPR): suitable

capacidad

1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)

temp. de almacenamiento

−20°C

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Aplicación

Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.

Acciones bioquímicas o fisiológicas

Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.

Envase

Package size based on protein content

Calidad

Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.

Forma física

Lyophilized powder containing buffer salt as sodium citrate

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000387622
0000316185
0000316185
0000387622
051M7670V

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LRP2 mediates folate uptake in the developing neural tube
Kur E, et al.
Journal of Cell Science, jcs-140145 (2014)
Radioassay of serum folate.
R T Dunn et al.
Clinical chemistry, 19(10), 1101-1105 (1973-10-01)
Martin D Forster et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 71(11), 945-950 (2007-08-23)
The alpha-folate receptor (alpha-FR) is a folate transporter with restricted expression levels in normal tissues. It is over-expressed in several cancers, particularly epithelial carcinomas, including nonmucinous ovarian carcinoma. It offers a novel therapeutic target for selective imaging and cytotoxic agents.
J F Ross et al.
Cancer, 73(9), 2432-2443 (1994-05-01)
Despite significant differences in ligand binding between the two known isoforms of the human membrane folate receptor (FR), designated herein as FR-beta (placenta) and FR-alpha (placenta, KB cells), little is known about their tissue specificities, and there is no report
Radioisotopic assay for measurement of serum folate levels.
S Waxman et al.
Blood, 38(2), 219-228 (1971-08-01)
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