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D9150

Sigma-Aldrich

2,3-Dimethoxy-5-methyl-p-benzoquinone

apoptosis inducer

Sinónimos:

Coenzyme Q0

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About This Item

Fórmula empírica (notación de Hill):
C9H10O4
Número de CAS:
605-94-7
Peso molecular:
182.17
Beilstein/REAXYS Number:
1640422
EC Number:
210-100-8
MDL number:
MFCD00001595
UNSPSC Code:
12352204
PubChem Substance ID:
24894261
NACRES:
NA.51

Quality Level

200

form

powder

mp

58-60 °C (lit.)

storage temp.

2-8°C

SMILES string

COC1=C(OC)C(=O)C(C)=CC1=O

InChI

1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3

InChI key

UIXPTCZPFCVOQF-UHFFFAOYSA-N

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General description

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0 or DMM) is present in all the cells including neural cells.

Application

2,3-Dimethoxy-5-methyl-p-benzoquinone has been used:
  • as a tau protein fibrillization inducer to determine the regions of tau involved in the formation of paired helical filaments (PHFs)
  • as a component in buffer B for cytochrome oxidation assay with subsaturating light
  • in the RPMI-1640 medium for 2,3-bis-(2-methoxy-4-nitro-5-sulphenyl)-(2H)-tetrazolium-5-carboxanilide (XTT) assay to quantify antifungal activity

Coenzyme Q0 inhibits (via radical quenching) reactions of gamma-irradiation induced homolytic cleavage of O-glycoside bonds in polysaccharides. Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. It is toxic to other cells such as insulin producing cells.

Biochem/physiol Actions

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0) interacts with tau protein and aids in the formation of filamentous structure.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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XTT assay of antifungal activity
Loures FV and Levitz SM
PLoS Pathogens, 5(15), e1543-e1543 (2015)
In vitro tau fibrillization: mapping protein regions
Santa-Maria I, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1762(7), 683-692 (2006)
The Photosynthetic Bacterial Reaction Center: Structure and Dynamics, 114-114 (2013)
Stanislaw Schmidt et al.
Pathogens (Basel, Switzerland), 8(4) (2019-11-23)
As the prognosis of invasive aspergillosis remains unacceptably poor in patients undergoing hematopoietic stem cell transplantation (HSCT), there is a growing interest in the adoptive transfer of antifungal effector cells, such as Natural Killer (NK) cells. Because immunosuppressive agents are
Stefania Fiorcari et al.
Frontiers in immunology, 11, 2158-2158 (2020-09-29)
Infections represent a cause of morbidity and mortality in patients affected by chronic lymphocytic leukemia (CLL). Introduction of new drugs in CLL clinical practice has showed impressive efficacy, in particular those targeting BTK. Among the consistent clinical data, an increasing
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