Saltar al contenido
Merck
Todas las fotos(2)

Documentos clave

Ver Toda la documentación

D2915

Sigma-Aldrich

Dexamethasone-Water Soluble

suitable for cell culture, BioReagent

Sinónimos:

Dexamethasone – Cyclodextrin complex

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(2)

About This Item

Número de CAS:
50-02-2
Número CE:
200-003-9
Número MDL:
MFCD00064136
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
329798758
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

synthetic (organic)

Línea del producto

BioReagent

Formulario

solid

técnicas

cell culture | mammalian: suitable

solubilidad

H2O: 25 mg/mL, clear to slightly hazy

Condiciones de envío

ambient

temp. de almacenamiento

room temp

cadena SMILES

C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)C3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO.OC[C@H]5O[C@@H]6O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]8[C@H](O)[C@@H](O)[C@H](O[C@@H]8CO)O[C@H]9[C@H](O)[C@@H](O)[C@H](O[C@@H]9CO)O[C@H]%10[C@H](O)[C@@H](O)[C@H](O[C@@H]%10CO)O[C@H]%11[C@H](O)[C@@H](O)[C@H](O[C@@H]%11CO)O[C@H]%12[C@H](O)[C@@H](O)[C@H](O[C@@H]%12CO)O[C@H]5[C@H](O)[C@H]6O

InChI

1S/C42H70O35.C22H30O4/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71-29)23(58)16(31)51;1-12-8-16-15-5-4-13-9-14(24)6-7-21(13,2)20(15)17(25)10-22(16,3)19(12)18(26)11-23/h8-63H,1-7H2;6-7,9,12,15-17,19-20,23,25H,4-5,8,10-11H2,1-3H3/t8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-;12-,15+,16?,17+,19-,20-,21+,22+/m11/s1

Clave InChI

XEJNDGTUKUMQNG-ARJMFYCQSA-N

Categorías relacionadas

Aplicación

Dexamethasone-Water Soluble has been used as a component of
  • Dulbecco′s modified Eagle medium based osteogenic and adipogenic medium for human mesenchymal stem cell culture[1]
  • erythroid expansion media for the growth of liver, bone marrow and spleen tissues[2]
  • medium 199 (M199) for hepatocyte culture[3]

Acciones bioquímicas o fisiológicas

Dexamethasone is an anti-inflammatory glucocorticoid[4] and a synthetic corticosteroid used for treating corneal inflammation. It inhibits the IL-1β-dependent angiogenesis.[5] Dexamethasone elicits a range of effects on cell survival, cell signaling and gene expression.[6] It favors apoptosis in chondrocytes and impairs development of bone.[7] Dexamethasone is a potential therapeutic agent as it induces apoptosis in multiple myeloma (MM) cells.[8] It elicits its functionality by lowering glucocorticoid receptor (GR) α levels and inhibits colon tumor progression.[9]

Envase

Package size based on dexamethasone

Otras notas

Contains approx. 65 mg dexamethasone per gram; balance methyl-β-cyclodextrin.

Producto relacionado

Referencia del producto
Descripción
Precios

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H360FD

Clasificaciones de peligro

Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
0000422275
0000422275
0000420180
0000420180
0000402362

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus
England SJ, et al.
Blood, 117(9), 2708-2717 (2011)
Dexamethasone-induced apoptotic mechanisms in myeloma cells investigated by analysis of mutant glucocorticoid receptors
Sharma S and Lichtenstein A
Blood, 112(4), 1338-1345 (2008)
Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis
Stremmel W, et al.
Faseb Journal, 28(7), 3159-3170 (2014)
Dexamethasone affects cell growthapoptosis chemosensitivity of colon cancer via glucocorticoid receptor alphaNF-kappaB
He J, et al.
Testing, 8(40), 67670-67670 (2017)
Mechanisms of dexamethasone-mediated inhibition of Toll-like receptor signaling induced by Neisseria meningitidis and Streptococcus pneumoniae
Mogensen TH, et al.
Infection and Immunity, 76(1), 189-197 (2008)
Ver todos los artículos relacionados

Questions

1–10 of 19 Questions  

  1. How long is Product D2915 stable in solid form?

    1 answer

    1. For certain products, the certificate of analysis may only display the Release Date, without a specified Retest, Expiration, or Use-by-Date. In such cases, the standard warranty of 1 year from the date of shipment applies. This product should remain stable in solid form for at least 1 year if stored correctly. For additional information on the warranty, refer to the terms and conditions of sale. Product Dating Information.

      Helpful?

  2. D2915 is light sensitive?

    1 answer

    1. This material is considered light sensitive and is packaged in amber glass bottles.

      Helpful?

  3. What is the molecular mass of Dexamethasone-Water Soluble (D2915)?

    1 answer

    1. This product is a multi-component item comprised of dexamethasone and (2-Hydroxypropyl)-?-cyclodextrin. The molecular weight of Dexamethasone is 392.5 g/mol. The molecular weight of the (2-Hydroxypropyl)-?-cyclodextrin is variable, but has an average molecular weight of 1,396 g/mol. There is an excess of cyclodextrin in the mixture to greatly enhance the solubility of the dexamethasone. The product is sold on the basis of the Dexamethasone content. The final product will have 55 - 75 mg of Dexamethasone per gram solid. For example, a 100mg package reporting a 75mg/gram Dexamethasone concentration would be a package of 1.81 grams. This value is reported in the Certiicate of Analysis. Please see the link below to review a sample of a specific Certificate:
      https://www.sigmaaldrich.com/US/en/product/sigma/d2915#product-information

      Helpful?

  4. How should stock solutions for item D2915-100MG be stored?

    1 answer

    1. Stock solutions can be stored for up to 2 months at -20°C.

      Helpful?

  5. What is the recommended method for storing prepared solutions of D2915 dexamethasone water-soluble?

    1 answer

    1. The recommended method for storing prepared solutions of D2915 dexamethasone water-soluble is to store the solutions in working aliquots at -20°C.

      Helpful?

  6. Is additional solubility data available for product D2915, Dexamethasone-Water Soluble?

    1 answer

    1. The solubility of product D2915, Dexamethasone-Water Soluble, has been tested only in water, with a solubility (turbidity) of clear to slightly hazy at 25 mg/mL in water. Additionally, It is also soluble in ethanol (25 mg/mL), DMSO (25 mg/mL), and DMF (25 mg/mL).

      Helpful?

  7. Is the 100mg labeled on the bottle of D2915 Dexamethasone for the total powder or the total dexamethasone?

    1 answer

    1. Each vial contains 100 mg of dexamethasone. The mg of dexamethasone per gram is provided on the label, typically around 65 mg/g.

      Helpful?

  8. Once this product has been reconstituted in water, how long can it be stored, and at what temperature?

    1 answer

    1. Stock solutions may be stored in working aliquots at -20ºC. Please see the link below for additional information on the Water Soluble Complexes, including Dexamethasone, Water Soluble:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/218/859/e8014inf.pdf

      Helpful?

  9. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  10. Do you have references for the use of Product D2915, Dexamethason - Water Soluble?

    1 answer

    1. Here is one reference that describes using Product No. D2915: Chang, C.-J., et al., Coactivator TIF1? Interacts with Transcription Factor C/EBP? and Glucocorticoid Receptor To Induce ?1-Acid Glycoprotein Gene Expression. Mol. Cell. Biol., 18(10), 5880-5887 (1998).

      Helpful?

1–10 of 19 Questions  

Reviews

No rating value

Active Filters

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico