D1069

Desloratadine

powder, ≥98% (HPLC)

• Sinónimos: 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex^®
• Fórmula empírica (notación de Hill): C₁₉H₁₉ClN₂
• Número de CAS: 100643-71-8
• Peso molecular: 310.82
• Número MDL: MFCD00871949
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329798668
• NACRES: NA.32

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• solubilidad: DMSO: >10 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1
• InChI: 1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
• Clave InChI: JAUOIFJMECXRGI-UHFFFAOYSA-N
• Información sobre el gen: human ... HRH1(3269)

Descripción

Aplicación

Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.

Acciones bioquímicas o fisiológicas

A non-sedating H₁-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.

Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

Información legal

Clarinex is a registered trademark of Schering Corp.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 390.2 °F - Pensky-Martens closed cup
• Punto de inflamabilidad (°C): 199 °C - Pensky-Martens closed cup