C7673
Monoclonal Anti-CD14 antibody produced in mouse
clone UCHM-1, purified immunoglobulin, buffered aqueous solution
Sinónimos:
Monoclonal Anti-CD14
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
mouse
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
UCHM-1, monoclonal
Formulario
buffered aqueous solution
mol peso
antigen 55 kDa
reactividad de especies
human
técnicas
flow cytometry: 5 μL using 1 × 106 cells
isotipo
IgG2a
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... CD14(929)
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Especificidad
The epitope recognized by this clone is sensitive to routine formalin fixation and paraffin embedding. Cryostat sections, post-fixed in formalin can be stained.
3rd Workshop: code no. 203
4th Workshop: code no. M24
3rd Workshop: code no. 203
4th Workshop: code no. M24
Inmunógeno
human thymocytes followed by peripheral blood T cells.
Aplicación
Monoclonal Anti-CD14 antibody produced in mouse is suitable for the following applications:
- Flow cytometry at a dilution of 5μL using 1 × 106 cells
- Immunofluorescence.
- Immunoblotting.
Acciones bioquímicas o fisiológicas
CD14 gene has an important role during signaling of the innate immune response and in the detection of inflammatory pathogens. It also plays an important role in recognizing tuberculosis (TB) disease and it can be used as a potential biomarker for predicting the prognosis of breast invasive ductal carcinoma with LN+ER/PR-Her2+. It is also associated with asthma, croup and allergy.
Descripción de destino
CD14 is a phosphoinositol-linked, single-chain, human cell surface glycoprotein antigen which is found on most human peripheral blood monocytes, granulocytes and dendritic reticulum cells, and some tissue macrophages. CD14 may also be present on B cells. Soluble forms of CD14 are present in serum and urine. The antigen functions as an acceptor for LPS-binding protein complexes.
Forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Andrea D Lehmann et al.
Particle and fibre toxicology, 6, 26-26 (2009-10-10)
Using an in vitro triple cell co-culture model consisting of human epithelial cells (16HBE14o-), monocyte-derived macrophages and dendritic cells, it was recently demonstrated that macrophages and dendritic cells create a transepithelial network between the epithelial cells to capture antigens without
Weifeng He et al.
PloS one, 8(9), e75366-e75366 (2013-10-03)
In clinical practice, breast cancers with lymph node positive, ER/PR-negative and overexpressed human epidermal growth factor receptor 2 (LN+ER/PR-Her2+) have high risk of recurrence, but the effective biomarkers of prognostic for this type tumor are still lacking. Since breast cancers
Donna C Rennie et al.
Disease markers, 35(6), 765-771 (2013-12-19)
The CD14 gene has an important role in the detection of inflammatory provoking pathogens and in the ensuing signaling of the innate immune response. We assessed the role of CD14 C-159T, G-1359T in the expression of asthma, croup, and allergy
Melissa K Callahan et al.
Journal of leukocyte biology, 74(5), 846-856 (2003-09-10)
Expression of phosphatidylserine (PS) on the surface of both macrophages and their apoptotic targets is required for efficient phagocytosis. Monocytes, the precursors of macrophages, do not express PS on their surface and do not efficiently phagocytose apoptotic cells. We report
J Zhao et al.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 17(11), 1472-1478 (2013-10-16)
CD14 plays an important role in recognising the tuberculosis (TB) antigen and initiating immune response. CD14-159C/T polymorphism has been reported to be associated with susceptibility to TB in some, but not all studies. To comprehensively evaluate the correlation between CD14-159C/T
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