C7344

Cyclic adenosine diphosphate-ribose

≥90% (HPLC), lyophilized powder

• Sinónimos: ADP-cyclo[N¹:1′′]-ribose, Cyclic ADPR, cADP-ribose, cADPR
• Fórmula empírica (notación de Hill): C₁₅H₂₁N₅O₁₃P₂
• Número de CAS: 119340-53-3
• Peso molecular: 541.30
• Número MDL: MFCD00214262
• Código UNSPSC: 41106305
• NACRES: NA.51

Propiedades

• origen biológico: (Ovotestis from sea hare)
• Ensayo: ≥90% (HPLC)
• Formulario: lyophilized powder
• temp. de almacenamiento: −20°C
• cadena SMILES: O[C@H]1[C@@H](O)[C@H]2O[C@@H]1COP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)[n@H]4cnc5C(=N)[N@@H]2C=Nc45
• InChI: 1S/C15H21N5O13P2/c16-12-7-13-18-4-19(12)14-10(23)8(21)5(31-14)1-29-34(25,26)33-35(27,28)30-2-6-9(22)11(24)15(32-6)20(13)3-17-7/h3-6,8-11,14-16,21-24H,1-2H2,(H,25,26)(H,27,28)/t5-,6-,8-,9-,10-,11-,14-,15-/m1/s1
• Clave InChI: BQOHYSXSASDCEA-KEOHHSTQSA-N

Descripción

Aplicación

Cyclic adenosine diphosphate-ribose (cADPR) is an intracellular second messenger that mobilizes intracellular Ca²⁺ release from the sarcoplasmic reticulum through ryanodine receptors. CADPR is also a second messenger for glucose-induced insulin release from endocrine pancreas and for abscisic acid-induced calcium release in plants.

Cyclic adenosine diphosphate-ribose has been used to stimulate astrocytes to activate CD38 signaling. It has also been used as a supplement in buffered peptone water to recover S. enteritidis.

Acciones bioquímicas o fisiológicas

Mobilizes intracellular Ca²⁺; regulates Ca²⁺-induced Ca²⁺ release specifically blocked by ryanodine; second messenger for glucose-induced insulin release from the endocrine pancreas and for abscisic acid-induced calcium release in plants.

Envase

Package size based on nucleotide content.

Forma física

Lyophilized powder

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves