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C4832

Sigma-Aldrich

Ceramide 1-phosphate from bovine brain

~95%

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About This Item

Número de CAS:
128543-23-7
MDL number:
MFCD00678983
UNSPSC Code:
12352211
PubChem Substance ID:
24892731
NACRES:
NA.77

assay

~95%

Quality Level

200

form

powder

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCCCCCC(=O)N[C@@H](COP(O)(O)=O)[C@H](O)\C=C\CCCCCCCCCCCCC

InChI

1S/C36H72NO6P/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(39)37-34(33-43-44(40,41)42)35(38)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38H,3-28,30,32-33H2,1-2H3,(H,37,39)(H2,40,41,42)/b31-29+/t34-,35+/m0/s1

InChI key

ZQQLMECVOXKFJK-NXCSZAMKSA-N

Biochem/physiol Actions

Putative second messenger of agonist-stimulated sphingomyelin metabolism; may participate in cell regulation and transmembrane signaling.

Other Notes

Contains primarily stearic and nervonic acids.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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R Shinghal et al.
Journal of neurochemistry, 61(6), 2279-2285 (1993-12-01)
Recent studies have implicated sphingolipids in a variety of intracellular signaling systems. The finding that a calcium-stimulated ceramide kinase copurifies with neurotransmitter-containing vesicles suggests that ceramide, or one of its metabolites, has a role in neurotransmitter release. As a step
O Boudker et al.
The Journal of biological chemistry, 268(29), 22150-22155 (1993-10-15)
A calcium-dependent ceramide (Cer) kinase was recently detected in human leukemia (HL-60) cells (Kolesnick, R.N., and Hemer, M.R. (1990) J. Biol. Chem. 265, 18803-18808) where it may function in terminating the regulatory effects of Cer, and in synaptic vesicles (Bajjalieh
Shaowei Wang et al.
Molecular neurodegeneration, 16(1), 26-26 (2021-04-18)
Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer's disease (AD), but the mechanisms for this association are not clear. The activation of calcium-dependent cytosolic phospholipase A2 (cPLA2) is involved in
Chinmoy Sarkar et al.
Autophagy, 16(3), 466-485 (2019-06-27)
Lysosomal membrane permeabilization (LMP) is observed under many pathological conditions, leading to cellular dysfunction and death. However, the mechanisms by which lysosomal membranes become leaky in vivo are not clear. Our data demonstrate that LMP occurs in neurons following controlled

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