C3045

Colesterol

powder, BioReagent, suitable for cell culture, ≥99%

• Sinónimos: 3β-Hidroxi-5-colesteno, 5-Colesten-3β-ol
• Fórmula empírica (notación de Hill): C₂₇H₄₆O
• Número de CAS: 57-88-5
• Peso molecular: 386.65
• Beilstein: 1915888
• Número CE: 200-353-2
• Número MDL: MFCD00003646
• Código UNSPSC: 12352211
• eCl@ss: 39023139
• ID de la sustancia en PubChem: 24892329
• NACRES: NA.75

Propiedades

• origen biológico: ovine wool
• Nivel de calidad: 200
• Línea del producto: BioReagent
• Ensayo: ≥99%
• Formulario: powder
• técnicas: cell culture | mammalian: suitable
• bp: 360 °C (lit.)
• mp: 147-149 °C (lit.)
• solubilidad: H₂O: 0.002 mg/mL; Tween: soluble; ethanol: soluble; serum: soluble
• densidad: 1.067 g/mL at 25 °C (lit.)
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• Clave InChI: HVYWMOMLDIMFJA-DPAQBDIFSA-N
• Información sobre el gen: human ... POLA1(5422) , TOP2A(7153) ; rat ... Ar(24208) , Polb(29240)

Descripción

Descripción general

Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals[1] and coordinates endocytosis.[2] It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia.[2] Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease.[1] Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development.[3] High cholesterol levels favor breast cancer progression.[4]

Aplicación

Cholesterol has been used:

• as a medium supplement in chorionic villous tissue culture form placenta[5]
• as a component of hormone pellet for implantation in mice ovary[6]
• for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1[7]

Acciones bioquímicas o fisiológicas

Componente principal de todas las membranas biológicas; ~ el 25 % de todos los lípidos cerebrales es colesterol.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)