C1104
Monoclonal Anti-Caspase 7 antibody produced in rat
clone 11E4, purified immunoglobulin, buffered aqueous solution
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About This Item
Productos recomendados
origen biológico
rat
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
11E4, monoclonal
Formulario
buffered aqueous solution
mol peso
antigen (full length) 35 kDa
antigen (subunit) 20 kDa
reactividad de especies
human
técnicas
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 2-4 μg/mL using a whole extract of cultured human acute T cell leukemia Jurkat cells
isotipo
IgG2a
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... CASP7(840)
Descripción general
Caspase-7 is a apoptosis-related cysteine peptidase, commonly known as CASP7. It is a human protein encoded by the CASP7 gene. CASP7 is a member of the caspase (cysteine aspartate protease) family of proteins and is an executioner protein of apoptosis.
Inmunógeno
recombinant p20 subunit of human caspase-7.
Aplicación
Monoclonal Anti-Caspase 7 antibody produced in rat is suitable for the following applications:
- Immunoprecipitation
- Microarray
- Western blotting at a concentration of 2-4μg/mL using a whole extract of cultured human acute T cell leukemia Jurkat cells.
Acciones bioquímicas o fisiológicas
Caspase-3 and -7 plays a central role in the execution-phase of cell apoptosis. The gene for caspase 7 (also known as Mch3, CMH-1 and ICELAP3) encodes a “short” prodomain protein product of 35 kDa that belongs to the Ced3/ICE family of cysteine proteases. Caspase 7 undergoes acleavage upon activation by caspase-3, -9 and -10, and granzyme B, leading to p20 and p12 subunits. It is an important intracellular effector of granzyme B-mediated apoptosis and cytotoxic Tlymphocyte- induced cell killing in vivo. Monoclonal antibodies reacting specifically with caspase 7 are useful tools for the study of protease networks involved in development and regulation and governing the life and death of cells and tissues.
Nota de preparación
The antibody is purified from culture supernatant of hybridoma cells grown in a bioreactor.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Witold A Witkowski et al.
Protein science : a publication of the Protein Society, 20(8), 1421-1431 (2011-06-16)
Caspases are a powerful class of cysteine proteases. Introduction of activated caspases in healthy or cancerous cells results in induction of apoptotic cell death. In this study, we have designed and characterized a version of caspase-7 that can be inactivated
A M Chinnaiyan et al.
Current biology : CB, 6(7), 897-899 (1996-07-01)
Cytotoxic T lymphocytes (CTLs) and natural killers (NK) cells provide immune surveillance against viruses and neoplasms, and play a central role in the pathogenesis of autoimmune disease, AIDS and graft rejection. Thus, it is important to understand the precise molecular
Andi Muhammad Ichsan et al.
International journal of retina and vitreous, 8(1), 40-40 (2022-06-18)
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes. Retinol and α-tocopherol of diabetic models prevent the damage of photoreceptor and retinal ganglion cells (RGC) caused by hyperglycemia. This study aims to examine the effect of retinol and
J M Chandler et al.
The Journal of biological chemistry, 273(18), 10815-10818 (1998-06-06)
Caspases plays a key role in the execution phase of apoptosis. "Initiator" caspases, such as caspase-8, activate "effector" caspases, such as caspase-3 and -7, which subsequently cleave cellular substrates thereby precipitating the dramatic morphological changes of apoptosis. Following treatment of
H Duan et al.
The Journal of biological chemistry, 271(3), 1621-1625 (1996-01-19)
Members of the ICE/ced-3 gene family have been implicated as components of the cell death pathway. Based on similarities with the structural prototype interleukin-1 beta-converting enzyme (ICE), family members are synthesized as proenzymes that are proteolytically processed to form active
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