C0246

Cabergoline

≥98% (HPLC)

• Sinónimos: 1-Ethyl-3-(3′-dimethylaminopropyl)-3-(6′-allylergoline-8′β-carbonyl)urea, 1-[(6-Allylergoline-8β-yl)carbonyl]-1-[3-(dimethylamino)-propyl]-3-ethylurea, Cabaser, Dostinex, FCE-21336
• Fórmula empírica (notación de Hill): C₂₆H₃₇N₅O₂
• Número de CAS: 81409-90-7
• Peso molecular: 451.60
• Número MDL: MFCD00867887
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329774771
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• actividad óptica: [α]/D −63 to −74°, c = 0.5 in dichloromethane
• solubilidad: DMSO: ≥10 mg/mL
• emisor: Johnson & Johnson
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(CC=C)C1
• InChI: 1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1
• Clave InChI: KORNTPPJEAJQIU-KJXAQDMKSA-N
• Información sobre el gen: human ... DRD2(1813)

Descripción

Acciones bioquímicas o fisiológicas

Cabergoline, a lysergic acid amide derivative, is a potent dopamine D2 receptor agonist. It also acts on dopamine receptors in lactophilic hypothalamus cells to suppress prolactin production in the pituitary gland. It has been used for monotherapy of Parkinson′s disease in the early phase; combination therapy, together with levodopa and a decarboxylase inhibitor such as carbidopa, in progressive-phase Parkinson′s disease and adjunctive therapy of prolactin-producing pituitary gland tumors (microprolactinomas).

Dopamine D2-receptor agonist; Prolactin inhibitor; Antiparkinsonian

Características y beneficios

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H362
• Consejos de prudencia: P202 - P260 - P263 - P264 - P301 + P312 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 4 Oral - Lact.
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable