B7283

Benserazide hydrochloride

≥98% (HPLC), solid, L-aromatic amino acid decarboxylase inhibitor

• Sinónimos: DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
• Fórmula empírica (notación de Hill): C₁₀H₁₅N₃O₅ · HCl
• Número CAS: 14919-77-8
• Peso molecular: 293.70
• NACRES: NA.77
• PubChem Substance ID: 24277886
• UNSPSC Code: 12352125
• EC Number: 238-991-9
• MDL number: MFCD00078571
• Assay: ≥98% (HPLC)
• Form: solid

Propiedades

• Nombre del producto: Benserazide hydrochloride, ≥98% (HPLC), solid
• biological source: synthetic
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: H₂O: 10 mg/mL
• originator: Roche
• storage temp.: room temp
• SMILES string: Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O
• InChI: 1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H
• InChI key: ULFCBIUXQQYDEI-UHFFFAOYSA-N
• Gene Information: human ... DDC(1644)

Descripción

General description

Benserazide is a peripheral decarboxylase inhibitor.

Application

Benserazide has been used:

• to inhibit dopa-decarboxylase
• to induce dyskinesia
• to test on purified bacterial TDCs to assess the extent to which it could affect bacterial decarboxylases
• as a peripheral dopa decarboxylase inhibitor to treat mice

Biochem/physiol Actions

Inhibitor of L-aromatic amino acid decarboxylase.

Benserazide can block HK2 enzymatic activity in vitro. It is used along with levodopa to treat Parkinson′s disease.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 2
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Gloves