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Documentos

89510

Sigma-Aldrich

Poli(etilenglicol)

BioUltra, 8,000

Sinónimos:

PEG

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About This Item

Fórmula lineal:
H(OCH2CH2)nOH
Número de CAS:
25322-68-3
MDL number:
MFCD00081839
UNSPSC Code:
12352104
PubChem Substance ID:
24889230
NACRES:
NA.26

Quality Level

200

product line

BioUltra

form

solid

mol wt

Mr 7000-9000

impurities

insoluble matter:, passes filter test
≤0.001% peroxides (as H2O2):

pH

5.5-7.0 (25 °C, 50 mg/mL in H2O)

mp

61-64 °C

solubility

H2O: 50 mg/mL at 25 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤200 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

50 mg/mL in H2O

UV absorption

λ: 260 nm Amax: 0.09
λ: 280 nm Amax: 0.03

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Poly(ethylene glycol) (PEG) is a polymer of ethylene glycol units and is hydrophilic in nature. PEG has high hydration capacity and is structurally flexible. PEG has advantage as a drug conjugate due to biocompatibility and nonexistence of steric hindrances in its structure.

Application

Poly(ethylene glycol) has been used:
  • in the transformation buffer in yeast
  • as a constituent of dengue virus isolation buffer
  • for concentration of lentivirus particles
  • in the crystallization of herpesvirus nuclear egress complex (NEC)

Biochem/physiol Actions

The Food and Drug Administration (FDA) approved PEG as drug conjugates, is nonimmunogenic and safe. PEG is widely used as a reagent in biochemistry and molecular biology experiments. PEG conjugation improves solubility and dissolution of diabetes drug, Gliclazide. It is used in carbon nanotube functionalization. The presence of PEG 8000 in the tannin tree foliage improves metabolisable energy (ME) content and gas production.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Poli(etilenglicol) average Mn 6,000

Sigma-Aldrich

81260

Poli(etilenglicol)

Ananthakrishnan Soundaram Jeevarathinam et al.
Biosensors & bioelectronics, 126, 831-837 (2019-01-04)
Heparin is an indispensable drug in anticoagulation therapy but with a narrow therapeutic window, which dictates regular testing and dose adjustment. However, current monitoring tools have a long turnaround time or are operator intensive. In this work, we describe a
Expression, purification and crystallization of the herpesvirus nuclear egress complex (NEC)
Bigalke JM and Heldwein EE
Bio-protocol, 6(14), 44708-44708 (2016)
Rapid generation of long tandem DNA repeat arrays by homologous recombination in yeast to study their function in mammalian genomes
Noskov VN, et al.
Biological Procedures Online, 13(1), 8-8 (2011)
Immunogenicity of polyethylene glycol (PEG)
The open conference proceedings journal, 2(1) (2011)
Vijay Ramani et al.
Methods (San Diego, Calif.), 170, 61-68 (2019-09-20)
The highly dynamic nature of chromosome conformation and three-dimensional (3D) genome organization leads to cell-to-cell variability in chromatin interactions within a cell population, even if the cells of the population appear to be functionally homogeneous. Hence, although Hi-C is a
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Polyethylene Glycol (PEG) Selection Guide

Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications.

Polyethylene Glycol (PEG) Selection Guide

Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications.

Polyethylene Glycol (PEG) Selection Guide

Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications.

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