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43608

Sigma-Aldrich

3,3′-Dipropylthiadicarbocyanine iodide

suitable for fluorescence, ≥98.0% (TLC)

Sinónimos:

3-Propyl-2-[5-[3-propyl-2(3H)-benzothiazolylidene]-1,3-pentadienyl]benzothiazolium iodide, DiSC3(5)

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About This Item

Fórmula empírica (notación de Hill):
C25H27IN2S2
Número de CAS:
53213-94-8
Peso molecular:
546.53
MDL number:
MFCD00075033
UNSPSC Code:
12352116
PubChem Substance ID:
57650184
NACRES:
NA.32

Quality Level

100

assay

≥98.0% (TLC)

form

powder

mp

245 °C (dec.) (lit.)

solubility

DMF: soluble

fluorescence

λex 500 nm; λem 705 nm in DMF

suitability

suitable for fluorescence

SMILES string

[I-].CCCN1C(\Sc2ccccc12)=C\C=C\C=C\c3sc4ccccc4[n+]3CCC

InChI

1S/C25H27N2S2.HI/c1-3-18-26-20-12-8-10-14-22(20)28-24(26)16-6-5-7-17-25-27(19-4-2)21-13-9-11-15-23(21)29-25;/h5-17H,3-4,18-19H2,1-2H3;1H/q+1;/p-1

InChI key

GDEURKKLNUGTDA-UHFFFAOYSA-M

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Application

3,3′-Dipropylthiadicarbocyanine iodide [DiSC3(5)] is used as a fluorogenic probe to detect and measure changes in transmembrane potential or configuration induced by membrane altering agents.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Transmembrane potential measurements

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Journal of proteomics, 150, 242-251 (2016-10-25)
Daptomycin (DAP) is a novel lipopeptide antibiotic which exhibits excellent antibacterial activity against most clinically relevant Gram-positive bacteria, but the DAP-targeting protein molecules against host bacterial infection are far from clear. In order to discover bacterial protein response to DAP
Sonya E Neal et al.
Molecular biology of the cell, 28(21), 2773-2785 (2017-08-18)
Prokaryotes have aerobic and anaerobic electron acceptors for oxidative folding of periplasmic proteins. The mitochondrial intermembrane space has an analogous pathway with the oxidoreductase Mia40 and sulfhydryl oxidase Erv1, termed the mitochondrial intermembrane space assembly (MIA) pathway. The aerobic electron
Marie Markones et al.
Biophysical journal, 118(2), 294-302 (2019-12-18)
Membrane proteins are embedded in a complex lipid environment that influences their structure and function. One key feature of nearly all biological membranes is a distinct lipid asymmetry. However, the influence of membrane asymmetry on proteins is poorly understood, and
Ines Greco et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-25)
Methicillin-resistant Staphylococcus pseudintermedius (MRSP) constitutes an emerging health problem for companion animals in veterinary medicine. Therefore, discovery of novel antimicrobial agents for treatment of Staphylococcus-associated canine infections is urgently needed to reduce use of human antibiotics in veterinary medicine. In
M Síp et al.
Journal of photochemistry and photobiology. B, Biology, 4(3), 321-328 (1990-01-01)
The mechanism of carbocyanine dye diS-C3-(5) fluorescence intensity variations with transmembrane potential changes has been studied using time-resolved fluorescence spectroscopy. Clear evidence is given of the transmembrane-potential-dependent partition of the dye among various sites with different fluorescence lifetimes. It was
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