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115M-1

Sigma-Aldrich

CD15 (MMA) Mouse Monoclonal Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

MMA, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

Formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (115M-14)
vial of 0.5 mL concentrate (115M-15)
bottle of 1.0 mL predilute (115M-17)
vial of 1.0 mL concentrate (115M-16)
bottle of 7.0 mL predilute (115M-18)

fabricante / nombre comercial

Cell Marque®

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotipo

IgM

control

Hodgkin lymphoma

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic, membranous

Información sobre el gen

human ... FUT4(2526)

Descripción general

A positive reaction for CD15 combined with a negative reaction for LCA and other B and T lineage markers provides support for Reed-Sternberg cells found in Hodgkin′s disease. Also this antibody does not detect mesotheliomas making it a more frequently used antibody to distinguish epithelial mesothelioma from adenocarcinoma.

Calidad


IVD

IVD

IVD

RUO

Ligadura / enlace

CD15 Positive Control Slides, Product No. 115S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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S H Swerdlow et al.
American journal of clinical pathology, 85(3), 283-288 (1986-03-01)
Leu-M1, or MMA, originally was proposed as a differentiation antigen on myelomonocytic cells and was said to be useful as an aid in distinguishing lymphoid from myeloid leukemias. Subsequently, it was proposed by Hsu and Jaffe as a useful marker
G S Pinkus et al.
The American journal of pathology, 119(2), 244-252 (1985-05-01)
Monoclonal antibody to Leu-M1, a granulocyte-related differentiation antigen, represents a highly effective reagent for detection of diagnostic Reed-Sternberg (R-S) cells and variants in paraffin-embedded tissues of Hodgkin's disease. In 69 of 73 cases of Hodgkin's disease (41 nodular sclerosis, 25
R Wieczorek et al.
The American journal of pathology, 121(3), 374-380 (1985-12-01)
The Leu-M1 antigen has been recently proposed as a valuable immunodiagnostic marker of the Reed-Sternberg cells of Hodgkin's disease and to be particularly helpful is distinguishing Hodgkin's disease from other lymphoproliferative disorders such as peripheral T-cell lymphomas. In this study
K Skubitz, et al.
Leucocyte Typing IV, 800-805 (1989)
S M Hsu et al.
American journal of clinical pathology, 82(1), 29-32 (1984-07-01)
It has been suggested that the malignant cells of Hodgkin's disease (HD), Reed-Sternberg cells, and their mononuclear variants may be related to cells of the monocyte-histiocyte system. To test this hypothesis, 20 cases of HD were tested with nine antibodies

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