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Y0000684

Trimetoprim

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

2,4-Diamino-5-(3,4,5-trimetoxibencil)pirimidina, NSC 106568

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About This Item

Fórmula empírica (notación de Hill):
C14H18N4O3
Número de CAS:
738-70-5
Peso molecular:
290.32
Beilstein:
625127
Número MDL:
MFCD00036761
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329831095
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

trimethoprim

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

Clave InChI

IEDVJHCEMCRBQM-UHFFFAOYSA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Se utiliza principalmente como un antibacteriano. Inhibidor de la dihidrofolato reductasa con selectividad por la enzima procariota.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palabra de señalización

Warning

Frases de peligro

H302,H361d

Clasificaciones de peligro

Acute Tox. 4 Oral - Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Ivan Senta et al.
Water research, 47(2), 705-714 (2012-11-29)
Comprehensive study on the occurrence and fate of several classes of antimicrobials, including sulfonamides, trimethoprim, fluoroquinolones and macrolides, in Croatian municipal wastewaters was performed using an integrated approach, which comprised analysis of both dissolved and particulate fractions. A nation-wide screening
Khalid Tai et al.
PloS one, 7(9), e46269-e46269 (2012-10-03)
Regulating transgene expression in vivo by delivering oral drugs has been a long-time goal for the gene therapy field. A novel gene regulating system based on targeted proteasomal degradation has been recently developed. The system is based on a destabilizing
Kyuho Han et al.
Nature methods, 11(1), 86-93 (2013-11-12)
Protein concentrations are often regulated by dynamic changes in translation rates. Nevertheless, it has been challenging to directly monitor changes in translation in living cells. We have developed a reporter system to measure real-time changes of translation rates in human
J T Andersen et al.
Epidemiology and infection, 141(8), 1749-1755 (2012-09-27)
The antibiotic trimethoprim acts as a folate antagonist. Since trophoblasts are very sensitive to drugs that interfere with the folic acid cycle and thereby inhibit DNA synthesis, use of trimethoprim during the first trimester could be associated with miscarriage. A
Hai Liu et al.
Journal of hazardous materials, 235-236, 367-375 (2012-08-25)
The preparation of activated carbons (AC-H(x)P(y)O(z)) by four kinds of oxyacids of phosphorus (H(3)PO(4), H(4)P(2)O(7), HPO(3) and H(3)PO(3)) activation of lotus stalk (LS) was studied, with a particular focus on the effect of these H(x)P(y)O(z) on both surface chemistry and
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