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Documentos clave

Y0000507

Chlorpromazine impurity A

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Chlorpromazine sulfoxide, 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1- amine S-oxide

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About This Item

Fórmula empírica (notación de Hill):
C17H19ClN2OS
Número de CAS:
969-99-3
Peso molecular:
334.86
Código UNSPSC:
41116107
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

chlorpromazine

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

[S+]1(c2c(cc(cc2)Cl)N(c3c1cccc3)CCCN(C)C)[O-]

InChI

1S/C17H19ClN2OS/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)22(21)17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3

Clave InChI

QEPPAOXKZOTMPM-UHFFFAOYSA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Chlorpromazine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

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Descripción
Precios

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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S G Dahl et al.
Molecular pharmacology, 21(2), 409-414 (1982-03-01)
The 3-dimensional molecular structures of methotrimeprazine, methotrimeprazine sulfoxide, and chlorpromazine sulfoxide were examined by X-ray crystallography. Previous studies of their dopamine receptor binding affinities have indicated that both chlorpromazine sulfoxide and methotrimeprazine sulfoxide lack neuroleptic potency. The crystal structures of
Photobinding of chlorpromazine and its sulfoxide in vitro and in vivo.
S A Schoonderwoerd et al.
Photochemistry and photobiology, 48(5), 621-626 (1988-11-01)
Z Y Sahaf et al.
Naunyn-Schmiedeberg's archives of pharmacology, 333(4), 454-456 (1986-08-01)
Treatment of frog cutaneous-pectoris nerve-muscle preparations with calmidazolium (R 24571), a calmodulin-inhibitor, at concentrations of 2 X 10(-7) mol/l and 5 X 10(-7) mol/l had no discernable effect on MEPP amplitude. 10(-6) mol/l calmidazolium caused a small (10-35%) increase in
M Nakano et al.
Biochemical and biophysical research communications, 130(3), 952-956 (1985-08-15)
Chemiluminescence in visible region was detected, during peroxidase-catalyzed oxidation of chlorpromazine at pH7.5 (but not at pH4.25) or of propericiazine, both at pH7.5 and at pH4.25. Red colored intermediates, cation radicals, were produced and decayed in all enzymatic systems used.
J W Hubbard et al.
Therapeutic drug monitoring, 7(2), 222-228 (1985-01-01)
Pooled plasma from healthy volunteers was spiked with pure, synthetic chlorpromazine (CPZ), chlorpromazine sulfoxide (CPZSO), or chlorpromazine N-oxide (CPZNO), and then made alkaline with either sodium hydroxide or sodium carbonate. The samples were allowed to stand at room temperature for
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