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V0033000

Valproic acid

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

2-Propylpentanoic acid, Valproic acid

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About This Item

Fórmula lineal:
(CH3CH2CH2)2CHCO2H
Número de CAS:
99-66-1
Peso molecular:
144.21
Número MDL:
MFCD00002672
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329828882
NACRES:
NA.24

grado

pharmaceutical primary standard

Agency

EP Reference Standard

familia API

valproic acid

fabricante / nombre comercial

EDQM

índice de refracción

n20/D 1.425 (lit.)

bp

220 °C (lit.)

densidad

0.9 g/mL at 25 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

CCCC(C(O)=O)CCC

InChI

1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

Clave InChI

NIJJYAXOARWZEE-UHFFFAOYSA-N

Información sobre el gen

human ... ALDH5A1(7915)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Valproic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Palabra de señalización

Danger

Frases de peligro

H302,H315,H318,H360FD

Clasificaciones de peligro

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

231.8 °F - closed cup

Punto de inflamabilidad (°C)

111 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number

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Radu M Nanau et al.
Clinical biochemistry, 46(15), 1323-1338 (2013-06-25)
Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic profiles, as well as a relatively favorable safety profile. However, adverse drug reactions have been reported in relation with
Mattias Linde et al.
The Cochrane database of systematic reviews, 6(6), CD010611-CD010611 (2013-06-26)
Some antiepileptic drugs but not others are useful in clinical practice for the prophylaxis of migraine. This might be explained by the variety of actions of these drugs in the central nervous system. The present review is part of an
Chi-Tso Chiu et al.
Pharmacological reviews, 65(1), 105-142 (2013-01-10)
The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex interactions between genes and environment that drive deficits in cellular plasticity and resiliency. The therapeutic potential of
Taylor Chomiak et al.
Neurotoxicology and teratology, 36, 57-66 (2012-09-13)
Autism spectrum disorder (ASD) is a behaviourally defined brain disorder affecting approximately 1 in 88 children. Many pathological studies have shown that ASD is frequently associated with grey and white matter changes that can be described by their deviations from
Periyasamy Palsamy et al.
Experimental eye research, 121, 26-34 (2014-02-15)
Recent epidemiological studies confirm the prevalence of cataract in epileptic patients. Similarly, the drugs used to treat epilepsy also show the connection with increased cataract formation. In this present study, we investigated the suppression of Nrf2/Keap1 dependent antioxidant protection through
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