PHR1955

Mepivacaine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: Mepivacaine hydrochloride, 1-Methyl-2′,6′-pipecoloxylidine hydrochloride, N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride
• Fórmula empírica (notación de Hill): C₁₅H₂₂N₂O · HCl
• Número de CAS: 1722-62-9
• Peso molecular: 282.81
• Número CE: 217-023-9
• Número MDL: MFCD00144738
• Código UNSPSC: 41116107
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to BP 699; traceable to Ph. Eur. M0370000; traceable to USP 1387002
• familia API: mepivacaine
• CofA: current certificate can be downloaded
• envase: pkg of 500 mg
• aplicaciones: pharmaceutical
• Formato: neat
• temp. de almacenamiento: 2-30°C
• cadena SMILES: CN1CCCCC1C(NC2=C(C)C=CC=C2C)=O.Cl
• InChI: 1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H
• Clave InChI: RETIMRUQNCDCQB-UHFFFAOYSA-N
• Información sobre el gen: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Descripción

Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mepivacaine hydrochloride is a local anesthetic that is related chemically and pharmacologically to the amide-type local anesthetics. It is often administered via local infiltration, peripheral nerve block, etc.

Aplicación

Mepivacaine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

Local anesthetic. Reversibly blocks transient Na⁺ inward current, as well as the steady-state K⁺ outward current.

Local anesthetic. Reversibly blocks transient Na⁺ inward current, as well as the steady-state K⁺ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB1955 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301,H336
• Consejos de prudencia: P261 - P264 - P270 - P271 - P301 + P310 - P304 + P340 + P312
• Clasificaciones de peligro: Acute Tox. 3 Oral - STOT SE 3
• Órganos de actuación: Central nervous system
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable