B5887

Sodium butyrate

≥98.5% (GC)

• Sinónimos: Butyric acid sodium salt
• Fórmula lineal: CH₃CH₂CH₂COONa
• Número de CAS: 156-54-7
• Peso molecular: 110.09
• Beilstein: 3629439
• Número CE: 205-857-6
• Número MDL: MFCD00002816
• Código UNSPSC: 12352107
• ID de la sustancia en PubChem: 24891873
• NACRES: NA.25

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Ensayo: ≥98.5% (GC)
• Formulario: powder
• condiciones de almacenamiento: (Tightly closed. Dry.; Keep in a dry place. )
• técnicas: DNA amplification: suitable; cell based assay: suitable; inhibition assay: suitable
• color: white
• mp: 250-253 °C (lit.)
• solubilidad: water: 100 mg/mL, clear to slightly hazy, colorless
• trazas de catión: Na: 19.8-22.0% (anhydrous)
• idoneidad: suitable for DNA precipitation
• aplicaciones: cell analysis; life science and biopharma; lipidomics
• temp. de almacenamiento: room temp
• cadena SMILES: [Na+].CCCC([O-])=O
• InChI: 1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
• Clave InChI: MFBOGIVSZKQAPD-UHFFFAOYSA-M
• Información sobre el gen: mouse ... ENSMUSG00000061062(15181)

Descripción

Aplicación

Sodium butyrate has been used:

• as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
• as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
• to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Acciones bioquímicas o fisiológicas

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca²⁺ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

Precaución

Hygroscopic

Otras notas

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Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H315,H319
• Consejos de prudencia: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Clasificaciones de peligro: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves