61188

Losartan Potassium

• Sinónimos: 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt
• Fórmula empírica (notación de Hill): C₂₂H₂₂ClKN₆O
• Número de CAS: 124750-99-8
• Peso molecular: 461.00
• Beilstein: 5845770
• Número MDL: MFCD02092704
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329759382
• NACRES: NA.24

Propiedades

• Formulario: powder or crystals
• Nivel de calidad: 200
• caducidad: limited shelf life, expiry date on the label
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• impurezas: ≤0.5% water
• aplicaciones: forensics and toxicology; pharmaceutical (small molecule); veterinary
• cadena SMILES: CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
• InChI: 1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
• Clave InChI: OXCMYAYHXIHQOA-UHFFFAOYSA-N
• Información sobre el gen: human ... AGTR1(185)

Descripción

Descripción general

Losartan potassium has long lasting effects, and its efficacy is generally increased, when combined with the diuretic co-active hydrochlorothiazide.[1]

Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.[2]

Aplicación

Losartan potassium may be used as an analytical reference standard for the quantification of the analyte in the following:

• Pharmaceutical formulations using reversed-phase high-performance liquid chromatography[3][4][5] and UV-spectrophotometric techniques.[4]
• Rat plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique.[6]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Acciones bioquímicas o fisiológicas

Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.

orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist

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Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)