681674

Wnt Pathway Inhibitor XI, CCT036477

The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinónimos: Wnt Pathway Inhibitor XI, CCT036477, CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
• Fórmula empírica (notación de Hill): C₂₁H₁₈ClN₃
• Número de CAS: 305372-78-5
• Peso molecular: 347.84
• Número MDL: MFCD01831143
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (¹H-NMR)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: off-white
• solubilidad: DMSO: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Clc1ccc(cc1)C(Nc4ncccc4)c2c3c([nH]c2C)cccc3
• InChI: 1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)
• Clave InChI: IFOHRIXRQPOHQZ-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC₅₀ = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Ewan, K., et al. 2010. Cancer Res.70, 5963.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2