573096

STAT3 Inhibitor Peptide, Cell-Permeable

≥95% (HPLC), lyophilized solid, STAT3 inhibitor, Calbiochem^®

• Sinónimos: STAT3 Inhibitor Peptide, Cell-Permeable, PpYLKTK-mts, STAT3 Inhibitor IV
• Fórmula empírica (notación de Hill): C₉₂H₁₅₇N₂₀O₂₄P
• Peso molecular: 1958.32
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: STAT3 Inhibitor Peptide, Cell-Permeable, The STAT3 Inhibitor Peptide, Cell-Permeable controls the biological activity of STAT3.
• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: lyophilized solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: water: 1 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Supplied as a trifluoroacetate salt.

A cell-permeable analog of the Stat3-SH2 domain-binding phospho-peptide (Cat. No. 573095) that contains a C-terminal membrane translocating sequence (MTS) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat3-dependent Src transformation with no effect on Stat3-independent Ras transformation.

A cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. The unphosphorylated inactive control peptide is also available under Cat. No. 573105.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Blocker of Stat3 activation

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Secuencia

H-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH

Otras notas

Turkson, J., et al. 2001. J. Biol. Chem.276, 45443.
Rojas, M., et al. 1998. Nat. Biotechnol.16, 370.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable