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Documentos clave

375095

Millipore

Heparin, Sodium Salt, Porcine Intestinal Mucosa

Sinónimos:

Heparin, Sodium Salt, Porcine Intestinal Mucosa, HEP, Na

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About This Item

Número de CAS:
9041-08-1
Número MDL:
MFCD00081689
Código UNSPSC:
12352201
NACRES:
NA.79
En este momento no podemos mostrarle ni los precios ni la disponibilidad

descripción

Merck USA index - 14, 4653

Nivel de calidad

100

Formulario

lyophilized

actividad específica

≥160 USP units/mg dry wt

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze

impurezas

≤0.5 EU/mg Endotoxin

solubilidad

water: 50 mg/mL

Condiciones de envío

ambient

temp. de almacenamiento

15-25°C

cadena SMILES

[Na+].[S](=O)(=O)(NC1C(OC(C(C1O[S](=O)(=O)O)OC4OC(C(C(C4O[S](=O)(=O)O)O)O)C(=O)O)CO)OC2C(OC(C(C2O)O[S](=O)(=O)O)OC3C(OC(C(C3O)NC(=O)C)O)CO[S](=O)(=O)O)C(=O)O)O

InChI

1S/C26H42N2O37S5.Na/c1-4(30)27-7-9(31)13(6(56-23(7)39)3-55-67(43,44)45)58-26-19(65-70(52,53)54)12(34)16(20(62-26)22(37)38)60-24-8(28-66(40,41)42)15(63-68(46,47)48)14(5(2-29)57-24)59-25-18(64-69(49,50)51)11(33)10(32)17(61-25)21(35)36;/h5-20,23-26,28-29,31-

Clave InChI

JRTRSJGZMRQDHI-UHFFFAOYSA-N

Descripción general

M.W. 13,500-15,000. Note: 1 KU = 1000 units.
MW: 15,000 ± 2,000
Preservative-free, non-sterile. Highly sulfated dextrorotatory mucopolysaccharide with specific anticoagulant properties. Inhibits IP3-activated Ca2+ channel release of the endoplasmic reticulum. Reported to activate the ryanodine receptor. Note: 1 KU = 1000 units. MW: 15,000 ± 2,000.

Advertencia

Toxicity: Harmful (C)

Otras notas

Seuwen, K., and Boddeke, H.G. 1995. Br. J. Pharmacol.114, 1613.
Ehrlich, B.E., et al. 1994. Trends Pharmacol. Sci.15,145.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Enrique Gómez et al.
Journal of proteome research, 19(3), 1169-1182 (2020-01-25)
Metabolomics may identify biomarkers in blood that differentiate pregnant from open embryo recipients. Fresh and vitrified/warmed, in vitro-produced embryos were transferred to Holstein recipients (discovery group). Recipient blood plasma collected on Day-0 (estrus) and Day-7 (before embryo transfer) were analyzed
Junxin Wang et al.
Bioconjugate chemistry, 29(11), 3768-3775 (2018-10-04)
We recently reported a real-time method to measure heparin in human whole blood based on the photoacoustic change of methylene blue (MB). Intriguingly, the MB behaved unlike other "turn on" photoacoustic probes-the absorbance decreased as the photoacoustic signal increased. The

Questions

1–2 of 2 Questions  

  1. I plan to use heparin in Neurobasal medium for culturing GBM cells. Literature suggests 2 µg/mL, but I need the units/mL for the final concentration. Could you provide guidance on the correct units/mL for heparin?

    1 answer

    1. Product 375095 is assayed for activity on a batch to batch basis with a specification for this product ≥160 USP units/mg dry weight. The reported activity value for this product will be found on the certificate of analysis for a given lot. It is unclear as to what activity corresponds to the provided concentration that was indicated and only the authors of the literature citation would know. Certain research articles do provide information on the activity of heparin to supplement neurobasal medium (NBM). Please see the article below which states NBM can be supplemented with 100 U/uL heparin. This decision will be at the discretion of the end user.

      https://www.sciencedirect.com/science/article/pii/S2666166723004884

      Helpful?

  2. What should be the storage temperature after 100 000 units of heparin salt is dissolved in 100 mL of PBS 1x

    1 answer

    1. Sterile filtered heparin solutions remain stable for up to 2 years when stored at 2-8 °C, provided th. Autoclaving and freezing heparin solutions are not recommended. Please see the link below to review additional information available in the datasheet for similar product H3393:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/112/608/h3393pis.pdf

      Helpful?

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