3301

17β-Estradiol

≥97% (HPLC), solid, estrogenic hormone, Calbiochem

• Sinónimos: 17β-Estradiol, 17 beta Estradiol
• Fórmula empírica (notación de Hill): C₁₈H₂₄O₂
• Número CAS: 50-28-2
• Peso molecular: 272.38
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00003693
• Assay: ≥97% (by assay)
• Form: solid
• Storage condition: OK to freeze

Propiedades

• Nombre del producto: 17β-Estradiol, Most potent mammalian estrogenic hormone.
• Quality Segment: 100
• description: RTECS - KG2975000; Merck USA index - 14, 3703
• assay: ≥97% (by assay)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to off-white
• solubility: ethanol: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: O[C@@H]1[C@@]2([C@H]([C@H]3[C@H](CC2)c4c(cc(cc4)O)CC3)CC1)C
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
• InChI key: VOXZDWNPVJITMN-ZBRFXRBCSA-N

Descripción

General description

17β-Estradiol is a potent estrogen, a steroid hormone, involved in reproductive and endocrine functions in mammals. It binds to estrogen receptors (ERα and ERβ) to regulate gene expression, influencing reproductive functions such as the proliferation of the uterine endometrium, ovulation, and maintenance of pregnancy. Additionally, 17β-Estradiol is involved in modulating metabolic processes, including lipid metabolism and insulin sensitivity, and exerts neuroprotective effects in the central nervous system.

Application

17β-Estradiol has been used to treat primary rat cortical neurons, to investigate its effects on neuronal responses to interleukin (IL)-6 and soluble IL-6 receptor treatment. It has also been administered subcutaneously to ovariectomized female mice to investigate its effects on Crhr1 and Esr1 mRNA expression in the nucleus accumbens.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Información de seguridad

• Pictogramas: GHS08,GHS09
• Palabra de advertencia: Danger
• Códigos de peligro: H351,H360Fd,H362,H410,EUH380,EUH430
• Indicaciones de precaución: P201 - P202 - P260 - P263 - P273 - P280 - P308 + P313 - P391 - P405 - P501
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• Hazard Classifications: Aquatic Chronic 1 - Carc. 2 - ED ENV 1 - ED HH 1 - Lact. - Repr. 1A