252805

DHEA

≥97% (HPLC), powder, GABAA receptor negative modulator, Calbiochem^®

• Sinónimos: DHEA, Dehydro- epi-androsterone, Dehydroisoandrosterone, Prasterone, 3-Hydroxyandrost-5-en-17-one
• Fórmula empírica (notación de Hill): C₁₉H₂₈O₂
• Número de CAS: 53-43-0
• Peso molecular: 288.42
• MDL number: MFCD00003613
• UNSPSC Code: 12352211
• NACRES: NA.77

Propiedades

• product name: DHEA, Major secretory steroidal product of the adrenal gland.
• Quality Level: 100
• assay: ≥97% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: ethanol: 20 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
• InChI key: FMGSKLZLMKYGDP-USOAJAOKSA-N

Descripción

General description

Major secretory steroidal product of the adrenal gland. DHEA and its sulfated metabolite, DHEA-S, are negative modulators of GABA_A receptors.

Major secretory steroidal product of the adrenal gland. DHEA, and its sulfated metobolite DHEA-S, are negative modulators of GABA_A receptors.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Negative modulators of GABAA receptors

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Other Notes

Hansen, S.L., et al. 1999. Mol. Pharmacol. 55, 489.
Imamura, M., and Prasad, C. 1998. Biochem. Biophys. Res. Commun.243, 771.
Majewska, M.D., et al. 1990. Brain Res.526, 143.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS08
• signalword: Warning
• hcodes: H361fd
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable