189513

Autotaxin Inhibitor IV, HA155

The Autotaxin Inhibitor IV, HA155 controls the biological activity of Autotaxin. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Sinónimos: Autotaxin Inhibitor IV, HA155, Atx Inhibitor IV, HA155, ( Z)-4-((4-((3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid, Atx Inhibitor IV, HA155, (Z)-4-((4-((3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid
• Fórmula empírica (notación de Hill): C₂₄H₁₉BFNO₅S
• Número de CAS: 1312201-00-5
• Peso molecular: 463.29
• Número MDL: MFCD28016544
• Código UNSPSC: 41121800
• NACRES: NA.28

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥99% (HPLC)
• Formulario: powder
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• color: yellow
• solubilidad: DMSO: 100 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: O=C(/C(S1)=C/C2=CC=C(OCC3=CC=C(B(O)O)C=C3)C=C2)N(CC4=CC=C(F)C=C4)C1=O
• Clave InChI: BRWUZCBSWABPMR-XKZIYDEJSA-N

Descripción

Descripción general

A ~5-fold more potent (IC₅₀ = 5.7 nM) para-isomer boronate analog of Autotaxin Inhibitor II, HA130 (Cat. No. 189511) that efficiently blocks thrombin-stimulated lysophosphatidic acid secretion in platelets and in mammalian cells.

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Fulkerson, Z., et al. 2011. J. Biol. Chem.286, 34654.
Hausmann, J., et al. 2011. Nat. Struct. Mol. Biol.18, 198.
Albers, H.M.H.G., et al. 2011. J. Med. Chem.54, 4619.
Albers, H.M.H.G., et al. 2010. J. Med. Chem.53, 4958.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable