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Merck
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Documentos clave

07-618

Sigma-Aldrich

Anti-SF-1 Antibody

Upstate®, from rabbit

Sinónimos:

Anti-AD4BP, Anti-FTZ1, Anti-FTZF1, Anti-POF7, Anti-SF-1, Anti-SF1, Anti-SPGF8, Anti-SRXX4, Anti-SRXY3, Anti-hSF-1

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

polyclonal

reactividad de especies

mouse

fabricante / nombre comercial

Upstate®

técnicas

western blot: suitable

isotipo

IgG

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

dry ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

Descripción general

Steroidogenic factor-1 (SF-1) regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells.

Especificidad

Recognizes SF-1.

Inmunógeno

DNA binding domain of SF-1 from mouse, produced in E. coli as a GST fusion protein and partially purified via GST-agarose column chromatography

Aplicación

Anti-SF-1 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of SF-1 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Calidad

Routinely evaluated by immunoblot on RIPA lysates from Y1 cells

Descripción de destino

53 kDa

Forma física

Format: Purified
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Protein A purified

Almacenamiento y estabilidad

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Nota de análisis

Control
Y1 cell lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Steroidogenic factor-1 is an essential transcriptional activator for gonad-specific expression of promoter I of the rat prolactin receptor gene
Hu, Z, et al
The Journal of Biological Chemistry, 272, 14263-14271 (1997)
Steroidogenic factor-1: a key regulator of gonadotroph gene expression
Fowkes, R C and Burrin, J M
The Journal of Endocrinology, 177, 345-350 (2003)
Hormonal regulation of microRNA expression in steroid producing cells of the ovary, testis and adrenal gland.
Hu, Z; Shen, WJ; Cortez, Y; Tang, X; Liu, LF; Kraemer, FB; Azhar, S
Testing null
Louisa M Ludbrook et al.
Endocrinology, 153(4), 1948-1958 (2012-02-02)
Human DAX1 duplications cause dosage-sensitive sex reversal (DSS) whereby chromosomally XY individuals can develop as females due to gonadal dysgenesis. However, the mechanism of DSS-adrenal hypoplasia congenita on X, gene 1 (DAX1) action in the fetal testis is unknown. We
Yasmin M Vasquez et al.
Molecular endocrinology (Baltimore, Md.), 30(5), 518-532 (2016-03-29)
Epigenetic silencing of steroidogenic factor 1 (SF1) is lost in endometriosis, potentially contributing to de novo local steroidogenesis favoring inflammation and growth of ectopic endometrial tissue. In this study, we examine the impact of SF1 expression in the eutopic uterus

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