D-927
Doxepin hydrochloride solution
1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Fórmula empírica (notación de Hill):
C19H22ClNO
Número de CAS:
Peso molecular:
315.84
Código UNSPSC:
41116107
NACRES:
NA.24
Productos recomendados
grado
certified reference material
Nivel de calidad
Formulario
liquid
Características
Snap-N-Spike®/Snap-N-Shoot®
envase
ampule of 1 mL
fabricante / nombre comercial
Cerilliant®
concentración
1.0 mg/mL in methanol (as free base)
técnicas
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
aplicaciones
clinical testing
Formato
single component solution
temp. de almacenamiento
−20°C
cadena SMILES
CN(C)CC/C=C1C2=C(C=CC=C2)COC3=C/1C=CC=C3.[H]Cl
InChI
1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;
Clave InChI
MHNSPTUQQIYJOT-CULRIWENSA-N
Descripción general
Doxepin is a tricyclic antidepressant used for the treatment of sleep maintenance and sold under trade names such as Silenor® and Aponal. This analytical reference standard is appropriate for use as starting material in calibrators or controls for numerous LC/MS or GC/MS applications such as forensic analysis, clinical toxicology, urine drug testing, or pharmaceutical research.
Aplicación
- Magnetic Particle Spray Mass Spectrometry: This study utilizes advanced analytical techniques, potentially incorporating Doxepin hydrochloride as a standard in mass spectrometry, to improve detection sensitivities for antidepressants and other neuropharmacological agents (Venga Mendes and Figueiredo, 2024).
- Desipramine induces anti-inflammatory dorsal root ganglion transcriptional signatures: Though primarily about desipramine, the methodologies and findings could be paralleled in studies using Doxepin hydrochloride to understand its effects on neuroinflammation and pain management (Serafini et al., 2024).
- Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: Reviews the mitigation of toxicity from drugs like Doxepin hydrochloride, underscoring the importance of lipid emulsions in treating drug overdoses and adverse effects (Hwang and Sohn, 2024).
- Novel Ti surface coated with PVA hydrogel and chitosan nanoparticles with antibacterial drug release: While focused on surface coatings, the methodology could be adapted for controlled release studies of tricyclic antidepressants like Doxepin hydrochloride in biomedical applications (Carrazco Ávila et al., 2024).
- Doxepin is more effective than zolpidem in improving executive function in patients with insomnia disorder: This clinical study on Doxepin could relate directly to Doxepin hydrochloride′s use in sleep medicine and psychiatric research, illustrating its efficacy and therapeutic potential (Yu et al., 2023).
Información legal
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Silenor is a registered trademark of Somaxon Pharmaceuticals, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Producto relacionado
Referencia del producto
Descripción
Precios
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Órganos de actuación
Eyes
Código de clase de almacenamiento
3 - Flammable liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
49.5 °F - closed cup
Punto de inflamabilidad (°C)
9.7 °C - closed cup
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Adam Wichniak et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 31(181), 65-70 (2011-08-30)
Disturbed sleep is a core symptom of depression and is among diagnostic criteria for depressive episode. Effects of an antidepressant drug on sleep are important for its clinical profile. Rapid improvement of sleep quality is particularly indicated in depressed patients
Yunes Panahi et al.
Skinmed, 9(3), 152-158 (2011-06-17)
Oral doxepin was shown to reduce chronic pruritus due to sulfur mustard. The present study compared the effects of topical doxepin 5% with betamethasone 1% for the treatment of pruritus in veterans exposed to sulfur mustard. This investigator-blinded, randomized, clinical
Yuliya Levintova et al.
International journal of pharmaceutics, 419(1-2), 96-106 (2011-08-02)
When liquid donors/receivers are used for in vitro skin permeation studies, excess hydration can change skin properties compared to in vivo conditions. A novel in vitro method of determining the permeability of drugs through skin was developed that avoids exposing
James L Zazzali et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 108(2), 98-102 (2012-02-01)
The literature on chronic idiopathic urticaria (CIU) lacks large-scale population-based studies. To characterize an insured population with CIU, including their demographic characteristics and comorbidities. We conducted a cross-sectional analysis using insurance claims. We included patients with 1 outpatient claim with
Xueqing Hu et al.
Neurochemistry international, 61(2), 207-218 (2012-05-09)
5-HT receptor changes remain controversial in posttraumatic stress disorder (PTSD) models. This study looks at the relationship between traumatic injuries and the alterations in 5-HT(2A) and 5-HT(2C) receptors in the goldfish brain. The effect of treatment with doxepin and fluoxetine
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