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QBD10314

Sigma-Aldrich

MAL-dPEG®24-NHS ester

Sinónimos:

Polyethylene glycol

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About This Item

Fórmula empírica (notación de Hill):
C62H111N3O31
Peso molecular:
1394.55
MDL number:
MFCD11041160
UNSPSC Code:
12352108
PubChem Substance ID:
329823914
NACRES:
NA.22
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assay

>90%

form

solid or viscous liquid

reaction suitability

reactivity: thiol reactive
reagent type: cross-linking reagent
reactivity: amine reactive

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)CCN2C(C=CC2=O)=O

InChI

1S/C62H111N3O31/c66-57(5-8-64-58(67)1-2-59(64)68)63-7-10-73-12-14-75-16-18-77-20-22-79-24-26-81-28-30-83-32-34-85-36-38-87-40-42-89-44-46-91-48-50-93-52-54-95-56-55-94-53-51-92-49-47-90-45-43-88-41-39-86-37-35-84-33-31-82-29-27-80-25-23-78-21-19-76-17-15-

InChI key

GRDUWUCYIIEBIS-UHFFFAOYSA-N

Features and Benefits

MAL-dPEG® 24-NHS ester is a heterobifunctional, linear crosslinking reagents containing a maleimide group on one end of the single molecular weight dPEG® spacer arm and an amine-reactive active ester on the other end. The number following the dPEG® refers to the exact number of spacer units present in the spacer arm. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. N-hydroxysuccinimide (NHS) ester are used widely in reactions with primary amines. The NHS-amine reactions can be carried out in aqueous or organic solvent. The dPEG® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Questions

  1. MI SAPETE DIRE IN CHE SOLVENTE LO POSSO SOLUBILIZZARE?

    1 answer

    1. This product is soluble in water and aqueous buffers. It is recommended to prepare solutions fresh as solutions will degrade quickly. At pH 7.0 – 7.5, NHS esters react optimally with free amines. However, NHS esters can react with free amines with a pH as low as 6.0. As the pH increases, the hydrolysis rate of the NHS ester increases. Indeed, at pH 7 and 0°C, the NHS ester half-life is 4 to 5 hours in aqueous buffer, while at pH 8 and 25°C, the half-life of an NHS ester is 1 hour.

      Alternative solvents have been cited in the literature. Sources state that a stock solution of 10 mm Mal–dPEG24–NHS ester can be prepared in chloroform and subsequently diluted in dimethylformamide. See the link below to review this article:
      https://onlinelibrary.wiley.com/doi/full/10.1002/admt.202200490

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