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Merck
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M80202

Sigma-Aldrich

2-Methylquinoxaline

97%

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About This Item

Fórmula empírica (notación de Hill):
C9H8N2
Número de CAS:
7251-61-8
Peso molecular:
144.17
Beilstein/REAXYS Number:
113307
EC Number:
230-664-9
MDL number:
MFCD00006727
UNSPSC Code:
12352100
PubChem Substance ID:
24897213
NACRES:
NA.22

assay

97%

form

liquid

refractive index

n20/D 1.613 (lit.)

bp

245-247 °C (lit.)

density

1.118 g/mL at 25 °C (lit.)

SMILES string

Cc1cnc2ccccc2n1

InChI

1S/C9H8N2/c1-7-6-10-8-4-2-3-5-9(8)11-7/h2-6H,1H3

InChI key

ALHUXMDEZNLFTA-UHFFFAOYSA-N

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

224.6 °F - closed cup

flash_point_c

107 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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F W Chaplen et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(10), 5533-5538 (1998-05-20)
Methylglyoxal is an alpha-ketoaldehyde and dicarbonyl formed in cells as a side product of normal metabolism. Endogenously produced dicarbonyls, such as methylglyoxal, are involved in numerous pathogenic processes in vivo, including carcinogenesis and advanced glycation end-product formation; advanced glycation end-products
Determination of methylglyoxal as 2-methylquinoxaline by high-performance liquid chromatography and its application to biological samples.
S Ohmori et al.
Journal of chromatography, 414(1), 149-155 (1987-02-20)
Fadhel A Alomar et al.
Antioxidants (Basel, Switzerland), 9(7) (2020-07-10)
Accumulation of methylglyoxal (MG) arising from downregulation of its primary degrading enzyme glyoxalase-1 (Glo1) is an underlying cause of diabetic cardiomyopathy (DC). This study investigated if expressing Glo1 in rat hearts shortly after the onset of Type 1 diabetes mellitus
Methylglyoxal assay in cells as 2-methylquinoxaline using 1,2-diaminobenzene as derivatizing reagent.
C Cordeiro et al.
Analytical biochemistry, 234(2), 221-224 (1996-02-15)
Weerachat Sompong et al.
BMC complementary and alternative medicine, 15, 394-394 (2015-11-02)
Methylglyoxal (MG) is one of the most reactive glycating agents, which result the formation of advanced glycation end-products (AGEs) that have been implicated in the progression of age-related diseases. Inhibition of MG-induced AGE formation is the imperative approach for alleviating
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