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Merck

H31204

Sigma-Aldrich

9-Hydroxyfluorene

96%

Sinónimos:

9-Fluorenol

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About This Item

Fórmula empírica (notación de Hill):
C13H10O
Número de CAS:
Peso molecular:
182.22
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

assay

96%

mp

153-154 °C (lit.)

SMILES string

OC1c2ccccc2-c3ccccc13

InChI

1S/C13H10O/c14-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)13/h1-8,13-14H

InChI key

AFMVESZOYKHDBJ-UHFFFAOYSA-N

pictograms

Environment

signalword

Warning

hcodes

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound
C Chen et al.
Drug metabolism and disposition: the biological fate of chemicals, 12(4), 421-426 (1984-07-01)
Fluoren-9-ol and fluoren-9-one were used as model substrates to study microsomal metabolism of alcohols and carbonyl compounds. It was found that there was an oxidoreductase(s) present in the microsomal preparation that catalyzed interconversion of this alcohol and ketone using pyridine
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Microbial reduction of 9-fluorenone to 9-hydroxyfluorene in carbon-filtered water: a confounding factor in an aquatic bioassay of 9-fluorenone with larvae of the midge, Chironomus tentans (Fabr.).
P W O'Keefe et al.
Bulletin of environmental contamination and toxicology, 75(6), 1060-1066 (2006-01-13)

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