900848

4-Amino-2-trimethylsilanylethynyl-benzenesulfonyl fluoride

• Sinónimos: Amino sulfonyl fluoride TMS-alkyne, Probe building block
• Fórmula empírica (notación de Hill): C₁₁H₁₄FNO₂SSi
• Número de CAS: 2088828-95-7
• Peso molecular: 271.38
• UNSPSC Code: 12352200
• NACRES: NA.22

Propiedades

• form: liquid
• availability: available only in USA
• storage temp.: −20°C
• SMILES string: NC1=CC=C(S(=O)(F)=O)C(C#C[Si](C)(C)C)=C1

Descripción

Application

Used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and amine synthetic handle. When appended to a ligand or pharmacophore through its amine linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Información de seguridad

• pictograms: GHS02
• signalword: Danger
• hcodes: H242
• pcodes: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Storage Class: 5.2 - Organic peroxides and self-reacting hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable