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545996

Sigma-Aldrich

Seleno-L-cystine

95%, for peptide synthesis

Sinónimos:

(R,R)-3,3′-Diseleno-bis(2-aminopropionic acid), L-Selenocystine

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About This Item

Fórmula lineal:
CO2HCH(NH2)CH2(Se)2CH2CH(NH2)CO2H
Número de CAS:
29621-88-3
Peso molecular:
334.09
Beilstein/REAXYS Number:
1969559
MDL number:
MFCD00800971
UNSPSC Code:
12352209
PubChem Substance ID:
24878867
NACRES:
NA.22

product name

Seleno-L-cystine, 95%

Quality Level

100

assay

95%

form

powder or crystals

optical activity

[α]20/D −28°, c = 1 in NaOH

reaction suitability

reaction type: solution phase peptide synthesis

mp

224.5-229.5 °C (lit.)

application(s)

peptide synthesis

Storage temp.

2-8°C

SMILES string

N[C@@H](C[Se][Se]C[C@H](N)C(O)=O)C(O)=O

InChI

1S/C6H12N2O4Se2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

Inchi Key

JULROCUWKLNBSN-IMJSIDKUSA-N

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Application

Seleno-L-cystine can be used for the synthesis of:
  • Biologically active selenol compounds.
  • Non-natural selenylated diamino acids.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Andrzej Gawor et al.
Animals : an open access journal from MDPI, 10(5) (2020-05-13)
Identification and quantification of the selenium species in biological tissues is imperative, considering the need to properly understand its metabolism and its importance in various field of sciences, especially nutrition science. Although a number of studies deals with the speciation
Synthesis of novel Se-substituted selenocysteine derivatives as potential kidney selective prodrugs of biologically active selenol compounds: evaluation of kinetics of ?-elimination reactions in rat renal cytosol
Andreadou I, et al.
Journal of Medicinal Chemistry, 39(10), 2040-2046 (1996)
Novel selenium-containing non-natural diamino acids
Caputo R, et al.
Tetrahedron Letters, 48(8), 1425-1427 (2007)
Tianfeng Chen et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 63(2), 105-113 (2008-05-31)
Epidemiological and clinical studies have demonstrated that dietary supplementation of selenium (Se) could reduce the incidence of human cancers. In this study, selenocystine, a nutritionally available selenoamino acid, was identified as a novel agent with broad-spectrum antitumor activity. A panel
Rui Gusmão et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 17(2), 321-329 (2011-10-22)
Selenium-containing compounds play an important role in antioxidant defense systems, binding to toxic metals, preventing their uptake into cells, and thus protecting cells from metal-induced formation of reactive oxygen species. Here, we present a proposal for a relatively new method
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