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Key Documents

1000818

USP

Abiraterone acetate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate

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About This Item

Empirical Formula (Hill Notation):
C26H33NO2
CAS Number:
Molecular Weight:
391.55
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

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grade

pharmaceutical primary standard

API family

abiraterone

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C[C@]12C(C[C@@H](OC(C)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CC=CN=C5

InChI

1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1

InChI key

UVIQSJCZCSLXRZ-UBUQANBQSA-N

Gene Information

human ... CYP17A1(1586)

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Cadence Science 6011

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General description

Abiraterone acetate is a pro-drug of abiraterone[1] and a potent inhibitor of the enzyme CYP17, required for androgen biosynthesis in the adrenal glands, testes and prostate tissue.[2][3]

Application

Abiraterone acetate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Abiraterone Acetate Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Health hazardEnvironment

Signal Word

Danger

Hazard Statements

Hazard Classifications

Aquatic Chronic 1 - Repr. 1B - STOT RE 2

Target Organs

Endocrine system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Phase II study of abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer displaying bone flare discordant with serologic response
Ryan.JC, et al.
Clinical Cancer Research, 14(7), 4854-4861 (2011)
Abiraterone Acetate Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 40(6), 26-26 (2022)
Ryan.JC, et al.
Journal of Clinical Oncology, 28(9), 1481-1488 (2010)
Abiraterone Acetate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 40(6), 25-25 (2020)
Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer
Danila.CD, et al.
Journal of Clinical Oncology, 28(9), 1496- 1501 (2010)

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