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T7313

Sigma-Aldrich

1-[2-(Trifluoromethyl)phenyl]imidazole

Synonym(s):

TRIM

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About This Item

Empirical Formula (Hill Notation):
C10H7F3N2
CAS Number:
25371-96-4
Molecular Weight:
212.17
MDL number:
MFCD00041206
UNSPSC Code:
12352202
PubChem Substance ID:
24278754
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

Assay

≥98% (GC)

form

solid

solubility

DMSO: soluble 30 mg/mL

storage temp.

2-8°C

SMILES string

FC(F)(F)c1ccccc1-n2ccnc2

InChI

1S/C10H7F3N2/c11-10(12,13)8-3-1-2-4-9(8)15-6-5-14-7-15/h1-7H

InChI key

WZBWBNCQUTXYEL-UHFFFAOYSA-N

Gene Information

human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)

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Biochem/physiol Actions

Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Eva Šatović et al.
Scientific reports, 9(1), 19962-19962 (2019-12-29)
Terminal repeat retrotransposons in miniature (TRIMs) are small non-autonomous LTR retrotransposons consisting of two terminal direct repeats surrounding a short internal domain. The detection and characterization of these elements has been mainly limited to plants. Here we present the first
Vallo Volke et al.
Behavioural brain research, 140(1-2), 141-147 (2003-03-20)
Various inhibitors of nitric oxide synthase (NOS) have been shown to possess antidepressant- and anxiolytic-like properties in animal models. The aim of this study was to compare the behavioural effects of NOS inhibitor 7-nitroindazole (7-NI) with the more selective neuronal
R L Handy et al.
British journal of pharmacology, 119(2), 423-431 (1996-09-01)
1. The ability of a range of substituted imidazole compounds to inhibit mouse cerebellar neuronal nitric oxide synthase (nNOS), bovine aortic endothelial NOS (eNOS) and inducible NOS (iNOS) from lungs of endotoxin-pretreated rats was investigated. In each case the substrate
Jose A Adams et al.
Resuscitation, 74(3), 516-525 (2007-05-01)
Nitric oxide (NO) is a critical regulator of vascular tone, and signal transduction. NO is produced via three unique synthases (NOS); endothelial (eNOS), and neuronal (nNOS) are both constitutively expressed and inducible (iNOS) produced primarily after stimulation. NO has been
Dongmei Wu et al.
Resuscitation, 73(1), 144-153 (2007-02-24)
The purpose of the present study was to identify the roles of the three nitric oxide synthase (NOS) isoforms on whole body ischemia-reperfusion injury during cardiopulmonary resuscitation (CPR) with periodic acceleration (pGz) in pigs. Thirty-two anesthetized pigs (27.6+/-3.4 kg) were
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