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SML1353

Sigma-Aldrich

ML351

≥98% (HPLC)

Synonym(s):

5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile, CID 664510, ML 351, SID 104223766

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About This Item

Empirical Formula (Hill Notation):
C15H11N3O
CAS Number:
847163-28-4
Molecular Weight:
249.27
MDL number:
MFCD04183120
UNSPSC Code:
12352200
PubChem Substance ID:
329825808
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CNC1=C(C#N)N=C(O1)C2=C3C(C=CC=C3)=CC=C2

InChI

1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3

InChI key

DYXYXTDIFMDJIR-UHFFFAOYSA-N

Biochem/physiol Actions

ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. ML351 reduces infarct size in a mouse model of ischemic stroke.
ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000190122
0000190122
0000119567
0000085478
0000085477

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Sally E Wenzel et al.
Cell, 171(3), 628-641 (2017-10-21)
Ferroptosis is a form of programmed cell death that is pathogenic to several acute and chronic diseases and executed via oxygenation of polyunsaturated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsaturated fatty acids as substrates. Mechanisms of the
Lisa Mayr et al.
Nature communications, 11(1), 1775-1775 (2020-04-15)
The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by enrichment with the ω-6 polyunsaturated fatty acid (PUFA) arachidonic

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