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Key Documents

SML0683

Sigma-Aldrich

JNJ-40418677

≥98% (HPLC)

Synonym(s):

2-(S)-(3,5-Bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid

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About This Item

Empirical Formula (Hill Notation):
C26H22F6O2
CAS Number:
Molecular Weight:
480.44
UNSPSC Code:
12352200
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

originator

Johnson & Johnson

relevant disease(s)

Alzheimer′s disease

storage temp.

2-8°C

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This Item
H6278PZ0222SML1782
CATPB ≥98% (HPLC)

SML1782

CATPB

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 15 mg/mL, clear

solubility

methanol: 10 mg/mL, ethanol: 20 mg/mL (with heating)

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

originator

Johnson & Johnson

originator

AstraZeneca

originator

-

originator

-

Biochem/physiol Actions

JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC50 = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 4

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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