SMB00445

Ganoderic acid A

≥98% (HPLC)

• Synonym(s): (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid, (7β,15α,25R)-7,15-Dihydroxy-3,11,23-trioxo-lanost-8-en-26-oic acid
• Empirical Formula (Hill Notation): C₃₀H₄₄O₇
• CAS Number: 81907-62-2
• Molecular Weight: 516.67
• UNSPSC Code: 12352205
• PubChem Substance ID: 329825018
• NACRES: NA.25

Properties

• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: powder
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• SMILES string: OC(C(C)CC(C[C@@H](C)[C@H]1C[C@H](O)[C@@]([C@]1(C)CC2=O)(C)C3=C2[C@]4(C)C(C[C@@H]3O)C(C)(C)C(CC4)=O)=O)=O
• InChI: 1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16?,18-,19+,21?,23+,28+,29-,30+/m1/s1
• InChI key: DYOKDAQBNHPJFD-ZQEHRSJRSA-N

Description

General description

Ganoderic Acid A or GAA is one of the most abundant triterpenoids that is found in Ganoderma lucidum fungi. The chemical structure of GAA has a tetracyclic ring with a double bond and terminal carboxyl group on the branch.

Application

Ganoderic acid A has been used:

• to study its protective effects on hypoxia-induced rat cardiomyocytes (H9c2) cell injury
• as a reference standard to study its inhibitory and antiviral effects against groundnut bud necrosis virus (GBNV) infection in cowpea plants
• as a standard in Fourier transformed-infrared (FT-IR) spectroscopy for the analysis of secondary metabolites from Ganoderma lucidum

Biochem/physiol Actions

Ganoderic Acid A (GAA) improves lipid metabolism, gut microbiota composition, and hyperlipidemia in high-fat-diet (HFD)-fed mice. It is proven to be a potential therapeutic anticancer agent in several in vitro studies by suppressing cell proliferation in different cancer cells such as breast cancer, human hepatocellular carcinoma cells, and osteosarcoma. GAA displays neuroprotective activities against depression-like behaviors, inflammation, and neuronal damage in the post-stroke depression (PSD) rat model. It also displays anti-human immunodeficiency virus (HIV) activity.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable