SAB4502131

Anti-RNF138 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): E3 ubiquitin-protein ligase RNF138, NLK-associated RING finger protein, Nemo-like kinase-associated RING finger protein, RING finger protein 138
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 28 kDa
• species reactivity: human, mouse, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; western blot: 1:500-1:1000
• NCBI accession no.: Q8WVD3
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... RN138(51444)

Description

General description

Anti-RNF138 antibody detects endogenous levels of total RNF138 protein.

The RNF138 (RING (really interesting new gene) finger protein 138) gene is mapped to human chromosome 18q12.1 and is predominantly expressed in testis. It encodes an E3 ubiquitin ligase, which is a CaV2.1 (voltage gated calcium channel) binding protein. It is a 245 amino acid protein containing a RING (really interesting new gene) domain at the N-terminal, zinc fingers, and an ubiquitin interacting motif at the C-terminal.

Immunogen

The antiserum was produced against synthesized peptide derived from human RNF138.

Immunogen Range: 31-80

Biochem/physiol Actions

Upregulation of RNF138 (RING (really interesting new gene) finger protein 138) induces polyubiquitination and increases the synthesis/degradation of CaV2.1 (voltage gated calcium channel). In response to DNA damage, RNF138 is localized to the DNA damage site mediated by zinc fingers. Deletion of RNF138 increases the sensitivity to DNA damaging agents and chromosomal instability. RNF138 is upregulated in gliomas.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable