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Key Documents

SAB4300160

Sigma-Aldrich

Anti-phospho-BCR (pTyr177) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-ALL antibody produced in rabbit, Anti-BCR-ABL1 antibody produced in rabbit, Anti-BCR1 antibody produced in rabbit, Anti-CML antibody produced in rabbit, Anti-breakpoint cluster region antibody produced in rabbit

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About This Item

MDL number:
MFCD02686065
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~210 kDa

species reactivity

mouse, human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(P-F-YP-V-N)

NCBI accession no.

NP_004318.3

UniProt accession no.

P11274

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr177)

Gene Information

human ... BCR(613)

Immunogen

Peptide sequence around phosphorylation site of tyrosine 177 (P-F-Y(p)-V-N), according to the protein BCR.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yuki Tanaka et al.
Journal of immunology (Baltimore, Md. : 1950), 201(8), 2256-2263 (2018-09-12)
We recently reported that NF-κB-mediated inflammation caused by breakpoint cluster region (BCR) is dependent on the α subunit of casein kinase II (CK2α) complex. In the current study, we demonstrate that presenilin 1 (Psen1), which is a catalytic component of

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