S4572

SANT-1

≥98% (HPLC), powder, SHH antagonist

• Synonym(s): (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
• Empirical Formula (Hill Notation): C₂₃H₂₇N₅
• CAS Number: 304909-07-7
• Molecular Weight: 373.49
• MDL number: MFCD01827306
• UNSPSC Code: 51111800
• PubChem Substance ID: 329824548
• NACRES: NA.77

Properties

• product name: SANT-1, ≥98% (HPLC), powder
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: Cc1nn(-c2ccccc2)c(C)c1\C=N\N3CCN(CC3)Cc4ccccc4
• InChI: 1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
• InChI key: FOORCIAZMIWALX-JJIBRWJFSA-N

Description

Application

• SANT-1 has been used: to treat cells and study the effect of SANT1-mediated inhibition on hedgehog signaling
• in the generation of functional human pancreatic β cells in vitro
• to treat of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells² and chronic lymphocytic leukemia cells³ with SANT-1 induced cell death

Biochem/physiol Actions

SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.

SANT-1 is known to induce apoptosis via Ras/NF-κB pathway in glioblastoma cells.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves