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Key Documents

P2607

Sigma-Aldrich

PRE-084

solid

Synonym(s):

2-(4-morpholinethyl)-1-phenylcyclohexanecarboxylate hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H27NO3 · HCl
Molecular Weight:
353.88
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Pricing and availability is not currently available.

form

solid

solubility

H2O: ≤24 mg/mL

SMILES string

Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)c3ccccc3

InChI

1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H

InChI key

QUJWFJNHTBKCLU-UHFFFAOYSA-N

Gene Information

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This Item
L3169I2909S1688
PRE-084 solid

P2607

PRE-084

SR 57227A solid

S1688

SR 57227A

solubility

H2O: ≤24 mg/mL

solubility

DMSO: >5 mg/mL, H2O: 6 mg/mL

solubility

DMSO: ~24 mg/mL, H2O: insoluble

solubility

H2O: soluble 9 mg/mL

Gene Information

human ... OPRS1(10280)
rat ... Oprs1(29336), Slc6a3(24898)

Gene Information

-

Gene Information

-

Gene Information

human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)

Biochem/physiol Actions

PRE-084 is a potent and highly selective σ1 opioid receptor agonist. It offers neuroprotection upon embolic stroke.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Yuriko Kimura et al.
    PloS one, 8(10), e75760-e75760 (2013-10-12)
    Sigma-1 receptor (Sig-1R) is an integral membrane protein predominantly expressed in the endoplasmic reticulum. Sig-1R demonstrates a high affinity to various synthetic compounds including well-known psychotherapeutic drugs in the central nervous system (CNS). For that, it is considered as an
    Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats
    Allahtavakoli M and Jarrott B
    Brain Research Bulletin, 85(3-4), 219-224 (2011)
    Judit Hodrea et al.
    International journal of molecular sciences, 24(14) (2023-07-29)
    Primary open-angle glaucoma remains a global issue, lacking a definitive treatment. Increased intraocular pressure (IOP) is considered the primary risk factor of the disease and it can be caused by fibrotic-like changes in the trabecular meshwork (TM) such as increased
    T Maurice et al.
    British journal of pharmacology, 127(2), 335-342 (1999-06-29)
    1. Sigma (sigma) receptor ligands were previously reported to alleviate learning and memory impairments on several pharmacological and pathological rodent models of amnesia. Such effect was demonstrated as involving the sigma1 subtype of sigma receptor. 2. In this study, we
    Li-Li Ji et al.
    Molecular medicine reports, 16(4), 4987-4993 (2017-08-10)
    Accumulating evidence has demonstrated that the σ-1 receptor (σ‑1R) possesses neuroprotective effects and is a potential novel therapeutic target for certain psychiatric diseases, including post‑traumatic stress disorder (PTSD) accompanied with anxiety disorder. It has been reported that σ‑1R agonist treatment

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