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Merck

M9771

Sigma-Aldrich

N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin

elastase substrate

Synonym(s):

MeOSuc-AAPV-AMC

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About This Item

Empirical Formula (Hill Notation):
C31H41N5O9
CAS Number:
Molecular Weight:
627.69
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

COC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C31H41N5O9/c1-16(2)27(30(42)34-20-9-10-21-17(3)14-26(39)45-23(21)15-20)35-29(41)22-8-7-13-36(22)31(43)19(5)33-28(40)18(4)32-24(37)11-12-25(38)44-6/h9-10,14-16,18-19,22,27H,7-8,11-13H2,1-6H3,(H,32,37)(H,33,40)(H,34,42)(H,35,41)

InChI key

CMEUDEVBFFPSEI-UHFFFAOYSA-N

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This Item
S9761T0273A6220
solubility

chloroform: 50 mg/mL, clear, colorless

solubility

methanol: 50 mg/mL, clear, colorless

solubility

acetic acid: 10 mg/mL, clear, colorless

solubility

DMSO/DMF: 1 mg/mL

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Application

N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin has been used as a substrate in elastase assay[1] using bone marrow lysates[2] and pancreatic lysates.[3]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrates

Fluorogenic substrate for the assay of human leukocyte and porcine pancreatic elastase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Gerrit Wolters-Eisfeld et al.
Experimental & molecular medicine, 50(10), 1-13 (2018-10-12)
Cosmc is ubiquitously expressed and acts as a specific molecular chaperone assisting the folding and stability of core 1 synthase. Thus, it plays a crucial role in the biosynthesis of O-linked glycosylation of proteins. Here, we show that ablation of
Jonas Hahn et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1401-1414 (2018-08-22)
Papillon-Lefèvre syndrome (PLS) is characterized by nonfunctional neutrophil serine proteases (NSPs) and fulminant periodontal inflammation of unknown cause. Here we investigated neutrophil extracellular trap (NET)-associated aggregation and cytokine/chemokine-release/degradation by normal and NSP-deficient human and mouse granulocytes. Stimulated with solid or
Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases.
M J Castillo et al.
Analytical biochemistry, 99(1), 53-64 (1979-10-15)
D Polacek et al.
The Journal of biological chemistry, 261(5), 2057-2063 (1986-02-15)
In vitro incubation of human plasma low density lipoproteins (LDL) with human blood polymorphonuclear cells (PMN) for 1 h at 37 degrees C resulted in an increased (2-4-fold) release into the medium of an enzymatic activity which co-eluted with LDL
Gisele Pena de Oliveira et al.
Nutrients, 11(4) (2019-04-25)
The innate immune response plays an important role in the pathophysiology of acute respiratory distress syndrome (ARDS). Glutamine (Gln) decreases lung inflammation in experimental ARDS, but its impact on the formation of extracellular traps (ETs) in the lung is unknown.

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Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

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