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Key Documents

I4375

Sigma-Aldrich

Inosine 5′-diphosphate sodium salt

≥96%

Synonym(s):

IDP

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About This Item

Empirical Formula (Hill Notation):
C10H14N4O11P2
CAS Number:
Molecular Weight:
428.19
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51

biological source

microbial

Quality Level

Assay

≥96%

form

powder

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])([O-])=O)n2cnc3C(=O)NC=Nc23

InChI

1S/C10H14N4O11P2.3Na/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1

InChI key

CPIQGMJSIPVOOS-MSQVLRTGSA-K

Application

Inosine 5′-diphosphate sodium salt has been used for hystoenzymatic demonstration of nucleoside diphosphatase (NDPase).

Preparation Note

Prepared from muscle or bacterial ADP.

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

STOT SE 2

Target Organs

Eyes,Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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John A Duley et al.
Therapeutic drug monitoring, 27(5), 647-654 (2005-09-22)
Metabolism of thiopurine drugs--azathioprine, 6-mercaptopurine, and 6-thioguanine--has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine nucleotide (TGN). However, a sense of uncertainty about the usefulness of TGNs and other
Edwin K Jackson et al.
The Journal of pharmacology and experimental therapeutics, 321(2), 799-809 (2007-02-23)
Stimulation of adenylyl cyclase causes cellular efflux of cAMP, and cAMP (unlike adenosine) is stable in blood. Therefore, it is conceivable that cAMP could function as a circulating adenosine prohormone by local target-organ conversion of distally released cAMP to adenosine
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Lorke DE, et al.
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European journal of pharmacology, 577(1-3), 35-43 (2007-09-20)
In C6 glioma cells, adenine nucleotides, especially AMP, and adenosine inhibited cell proliferation in time- and concentration-dependent manners. alpha,beta-methylene-ADP, an ecto-5'-nucleotidase inhibitor, suppressed the hydrolysis of AMP and reversed the inhibition of cell growth induced by AMP but not by
CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model
Almolda B, et al.
Journal of Neuroimmunology, 209(1-2), 65-80 (2009)

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