E2031

Eliprodil

≥98% (HPLC), powder

• Synonym(s): α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, SL 820715
• Empirical Formula (Hill Notation): C₂₀H₂₃ClFNO
• CAS Number: 119431-25-3
• Molecular Weight: 347.85
• MDL number: MFCD00866651
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277709
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear; H₂O: insoluble
• originator: Sanofi Aventis
• storage temp.: 2-8°C
• SMILES string: OC(CN1CCC(CC1)Cc2ccc(F)cc2)c3ccc(Cl)cc3
• InChI: 1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2
• InChI key: GGUSQTSTQSHJAH-UHFFFAOYSA-N
• Gene Information: human ... GRIN2B(2904) ; rat ... Adra1a(29412)

Description

Biochem/physiol Actions

NR2B selective NMDA glutamate receptor antagonist which appears to target the "polyamine site" on the NMDA receptor, setting it apart from other NR2B receptor antagonists. Possesses neuroprotective effects in models of ischemia, but prolongs the QT interval in patients; currently under investigation for acute and chronic pain.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves