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biological source
plant (Croton tiglium L)
Quality Level
form
viscous liquid
density
0.94 g/mL at 25 °C (lit.)
functional group
ester
lipid type
oils
shipped in
ambient
storage temp.
room temp
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General description
Croton oil is a toxic viscous liquid extracted from seeds of Croton tiglium. It is pale yellow to brown in color and is transparent in nature. Croton oil has a strong irritant property and is used along with phenol in some chemical peels. It also has a tumor promoting ability.
Croton oil is extracted from Croton tiglium L. It consists of crotonoleic acid, crotonic acid, crotonyl alcohol, crotonyl alcohol bisester and crotonyl alcohol trisester. Croton oil acts as a stimulant in the skin and mucosal inflammation. It is associated with allergic contact dermatitis (ACD) and skin carcinoma. Croton oil functions as a skin peeling agent.
Application
Croton oil has been used to induce acute skin inflammation.
Croton oil has been used to induce inflammation in mouse ears.
Other Notes
Essential oil rich in glycerides of saturated fatty acids, and in phorbol esters.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
165.2 °F - closed cup
Flash Point(C)
74 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Thekkuttuparambil Ananthanarayanan Ajith et al.
Journal of experimental therapeutics & oncology, 9(3), 207-215 (2011-11-11)
The roles of 7,12-dimethylbenz[a]anthracene (DMBA), a polycyclic aromatic hydrocarbon (PAH), and 12-O-tetradecanoylphorbol-13-acetate (TPA) a skin tumor promoter present in croton oil, are clearly implicated in the formation of skin papilloma. The effect of ethyl acetate extract of Phellinus rimosus, a
Alireza Garjani et al.
Iranian biomedical journal, 16(2), 59-67 (2012-07-18)
A growing body of preclinical data indicates that statins may possess antineoplastic properties; however, some studies have raised the possibility that statins may also have carcinogenic potential. An air pouch model was used for angiogenesis. Single or multiple applications of
Direct effect of croton oil on intestinal epithelial cells and colonic smooth muscle cells
Wang X, et al.
World Journal of Gastroenterology, 8(1), 103-103 (2002)
Protein Kinase C in Oncogenic Transformation and Cell Polarity
Signal Transduction (2016)
Effects of Haruan (Channa striatus) Based Cream on Acute Inflammation in Croton Oil Induced Mice Ear Edema Model
Abedi S, et al.
Research Journal of Biological Sciences, 7(4), 181-187 (2012)
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